EFFECTIVENESS, OUTCOME, AND SAFETY OF VITAMIN D SUPPLEMENTATION IN PATIENTS WITH PSORIASIS: A COMPREHENSIVE SYSTEMATIC REVIEW
DOI:
https://doi.org/10.61841/srj2wg56Keywords:
Psoriasis, vitamin D supplementationAbstract
Background: Insights into psoriasis as a systemic ailment have spurred the investigation of novel therapies due to dissatisfaction with current treatments and significant quality of life impairment. Vitamin D3 deficiency is implicated in psoriasis pathophysiology, with studies highlighting its impact on keratinocyte regulation and autoimmune disease resistance. This review critically evaluates evidence on high-dose oral vitamin D3 supplementation for psoriasis management, aiming to assess its effectiveness, treatment outcomes, and safety profile to inform clinician.
Methods: This systematic review focused on full-text English literature published between 2017 and 2024 using the PRISMA 2020 guidelines. Editorials and review pieces published in the same journal as the submission without a DOI were not accepted. The literature was compiled using PubMed, ScienceDirect, and SagePub, among other online venues.
Result: Our research team initially collected numerous publications from credible sources such as Science Direct, PubMed, and JAMA Dermatology. Employing a meticulous three-tier screening approach, we identified only five papers that were directly pertinent to our ongoing systematic assessment. Subsequently, we conducted a comprehensive examination of the entire text and further selected articles; case control study, double-blind, randomized, placebo-controlled study, randomized controlled trial, a bidirectional two-sample mendelian randomization analysis, and observational cross-sectional study.
Conclusion: In conclusion, maintaining serum vitamin D levels above 30 ng/ml may benefit severe psoriasis, while oral vitamin D2 supplementation showed promise in mild cases. Larger trials are needed for severe psoriasis, and future research should explore higher doses. Additionally, a study found no support for monthly vitamin D3 supplementation in older mild psoriasis patients. We confirmed the causal link between vitamin D levels and psoriasis, identified associations with increased risk, and explored effects on atopic dermatitis. While no significant difference was found in serum vitamin D levels between psoriasis patients and controls, lower levels in psoriasis suggest various influences.
References
Efficacy and safety of vitamin D supplementation on psoriasis: A systematic review and meta-analysis. PLOS ONE 18(11): e0294239. https://doi.org/10.1371/journal.pone.0294239
Jenssen M, Furberg A, Jorde R, Wilsgaard T, Danielsen K. Effect of Vitamin D Supplementation on Psoriasis Severity in Patients With Lower-Range Serum 25-Hydroxyvitamin D Levels: A Randomized Clinical Trial. JAMA Dermatol. 2023;159(5):518–525. doi:10.1001/jamadermatol.2023.0357
Renu Mahtani, Pradeep M.K. Nair, Daily oral vitamin D3 without concomitant therapy in the management of psoriasis: A case series, Clinical Immunology Communications, Volume 2, 2022, Pages 17-22, ISSN 2772-6134, https://doi.org/10.1016/j.clicom.2022.01.001. (https://www.sciencedirect.com/science/article/pii/S2772613422000014)
Barrea L, Savanelli MC, Di Somma C, et al. Vitamin D and its role in psoriasis: An overview of the dermatologist and nutritionist. Rev Endocr Metab Disord. 2017;18(2):195-205. doi:10.1007/s11154-017-9411-6
Moosazadeh M, Damiani G, Khademloo M, Kheradmand M, Nabinezhad-Male F, Hessami A. Comparing Vitamin D Level Between Patients with Psoriasis and Healthy Individuals: A Systematic Review and Meta-Analysis. J Evid Based Integr Med. 2023;28:2515690X231211663. doi:10.1177/2515690X231211663
Formisano E, Proietti E, Borgarelli C, Pisciotta L. Psoriasis and Vitamin D: A Systematic Review and Meta-Analysis. Nutrients. 2023;15(15):3387. Published 2023 Jul 30. doi:10.3390/nu15153387
Brożyna AA, Slominski RM, Nedoszytko B, Zmijewski MA, Slominski AT. Vitamin D Signaling in Psoriasis: Pathogenesis and Therapy. International Journal of Molecular Sciences. 2022; 23(15):8575. https://doi.org/10.3390/ijms23158575
Kamangar F, Koo J, Heller M, Lee E, Bhutani T. Oral vitamin D, still a viable treatment option for psoriasis. J Dermatolog Treat. 2013;24(4):261-267. doi:10.3109/09546634.2011.643219
Gamonal SBL, Gamonal ACC, Marques NCV, Brandão MAF, Raposo NRB. Is vitamin D status relevant to psoriasis and psoriatic arthritis? A retrospective cross-sectional study. Sao Paulo Med J. 2022;141(3):e2022216. Published 2022 Sep 6. doi:10.1590/1516-3180.2022.0216.R1.01072022
Bhat, G.H., Guldin, S., Khan, M.S. Et Al. Vitamin D Status In Psoriasis: Impact And Clinical Correlations. Bmc Nutr 8, 115 (2022). https://doi.org/10.1186/s40795-022-00610-y
Disphanurat W, Viarasilpa W, Chakkavittumrong P, Pongcharoen P. The Clinical Effect Of Oral Vitamin D2 Supplementation On Psoriasis: A Double-Blind, Randomized, Placebo-Controlled Study. Dermatol Res Pract. 2019; 2019:5237642. Pmid:31139214
Paul Jarrett, Carlos Arturo Camargo Jr, Christin Coomarasamy & Robert Scragg (2017): A Randomized, Double-Blind, Placebo-Controlled Trial Of The Effect Of Monthly Vitamin D Supplementation In Mild Psoriasis, Journal Of Dermatological Treatment, doi: 10.1080/09546634.2017.1373735
Ren, Y.; Liu, J.; Li, W.; Zheng, H.; Dai, H.; Qiu, G.; Yu, D.; Yao, D.; Yin, X. Causal Associations Between Vitamin D Levels And Psoriasis, Atopic Dermatitis, And Vitiligo: A Bidirectional Two-Sample Mendelian Randomization Analysis. Nutrients 2022, 14, 5284. Https:// doi.org/10.3390/nu14245284
Fernandes, A., Listiawan, M. Y., Ervianti, E., & Setyaningrum, T. (2020). The Analysis Of Serum Vitamin D (25[Oh]D) Level In Psoriasis Patients Comparing With Control Subjects. Berkala Ilmu Kesehatan Kulit Dan Kelamin, 32(2), 111– 118. https://doi.org/10.20473/bikk.v32.2.2020.111-118
Zhang, Y.; Jing, D.; Zhou, G.; Xiao, Y.; Shen, M.; Chen, X.; Liu, H. Evidence of a Causal Relationship Between Vitamin D Status and Risk of Psoriasis from the UK Biobank Study. Front. Nutr. 2022, 9, 807344
Han JH, Lee JH, Han KD, Seo HM, Bang CH, Park YM, Lee JY, Park YG. Epidemiology and medication trends in patients with psoriasis: a nationwide population-based cohort study from Korea. Acta Derm Venereol 2018; 98(4):396-400.
Ito T, Takahashi H, Kawada A, Iizuka H, Nakagawa H. Epidemiological survey from 2009 to 2012 of psoriatic patients in japanese society for psoriasis research. J Dermatol 2018; 45(3):293-301.
Filoni A, Vestita M, Congedo M, Giudice G, Tafuri S, Bonamonte D. Association between psoriasis and vitamin D: duration of disease correlates with decreased vitamin D serum levels: an observational case-control study. Medicine (Baltimore) 2018; 97(25):1-4.
Maleki M, Nahidi Y, Azizahari S, Meibodi NT, Hadianfar A. Serum 25-OH vitamin D level in psoriatic patients and comparison with control subjects. J Cutan Med Surg 2016; 20(3):207-10.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Licensing
Ninety Nine Publication publishes articles under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This licensing allows for any use of the work, provided the original author(s) and source are credited, thereby facilitating the free exchange and use of research for the advancement of knowledge.
Detailed Licensing Terms
Attribution (BY): Users must give appropriate credit, provide a link to the license, and indicate if changes were made. Users may do so in any reasonable manner, but not in any way that suggests the licensor endorses them or their use.
No Additional Restrictions: Users may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
