ASSOCIATION OF VITAMIN D SERUM LEVELS AND OVARIAN CANCER: A SYSTEMATIC REVIEW
DOI:
https://doi.org/10.61841/kvxvf619Keywords:
Vitamin D, ovarian canceAbstract
Background: Knowing the modifiable risk factors for prevention and improved prognosis is crucial, as the prognosis of ovarian cancer is poor and there are few population-level interventions for early identification and long-term therapeutic success. Research on cancer has shown a great deal of scientific interest in vitamin D since it may be one of these factors.
Aims: This systematic review is to review the association of vitamin D serum levels in patients with ovarian cancer
Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and MetaAnalysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2014 and 2024 were taken into account. Several different online reference sources, like Pubmed and SCIENCE DIRECT, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.
Result: In the PubMed database, the results of our search brought up 329 articles, whereas the results of our search on SCIENCE DIRECT brought up 298 articles. The results of the search conducted for the last year of 2014 yielded a total 8 articles for PubMed and 12 articles for SCIENCE DIRECT. In the end, we compiled a total of 4 papers, 3 of which came from PubMed and 1 of which came from SCIENCE DIRECT. We included four research that met the criteria.
Conclusion: In summary, some of the studies showed vitamin D supplementation is not necessary to increase the survival rate of ovarian cancer in the absence of a vitamin D shortage. There are limited studies about the association of vitamin D and ovarian cancer.
References
Piatek K, Schepelmann M, Kallay E. The Effect of Vitamin D and Its Analogs in Ovarian Cancer. Vol. 14, Nutrients. MDPI; 2022.
Guo H, Guo J, Xie W, Yuan L, Sheng X. The role of vitamin D in ovarian cancer: Epidemiology, molecular mechanism and prevention. Vol. 11, Journal of Ovarian Research. BioMed Central Ltd.; 2018.
Gloss BS, Samimi G. Epigenetic biomarkers in epithelial ovarian cancer. Cancer Lett. 2014;342(2):257–63.
Webb P, Protani MM, de Fazio A, Ibiebele TI, Nagle CM. Circulating 25-hydroxyvitamin D and survival in women with ovarian cancer. Am J Clin Nutr. 2015;102(1):109–14.
Ross TL, Neale RE, Na R, Webb PM. Vitamin D status during and after treatment and ovarian cancer survival. Cancer Causes and Control. 2023 Jan 1;
Sajo EA, Okunade KS, Olorunfemi G, Rabiu KA, Anorlu RI. Serum vitamin D deficiency and risk of epithelial ovarian cancer in Lagos, Nigeria. ECancer Medical Science. 2020;
Kolnsberg L, Riffelmann M, Friedrich M. Comparison of serum 25-hydroxyVitamin D levels in patients with malignant and benign gynaecological disease. Anticancer Res. 2020;40(1):545–50.
L’Espérance K, Datta GD, Qureshi S, Koushik A. Vitamin D exposure and ovarian cancer risk and prognosis. Vol. 17, International Journal of Environmental Research and Public Health. MDPI AG; 2020.
Feldman D, Krishnan AV, Swami S, Giovannucci E, Feldman BJ. The role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer. 2014;14(5):342–57.
Holick MF. Vitamin D, sunlight and cancer connection. Anticancer Agents Med Chem. 2013;13(1):70– 82.
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