THE ANALYSIS STUDY OF EFFECTIVENESS OF VITAMIN D SUPPLEMENTATION IN ATOPIC DERMATITIS: A COMPREHENSIVE SYSTEMATIC REVIEW
DOI:
https://doi.org/10.61841/wyf5vn78Keywords:
Atopic dermatitis, vitamin D, outcomesAbstract
Background: Atopic dermatitis is a prevalent skin condition with a 10% lifetime prevalence, affecting 15%-20% of children and 1%-3% of adults globally. Atopic dermatitis is often multimorbid and more prone to allergic disorders. Vitamin D (VD) deficiency has been linked to an increase in allergy disorders and atopic dermatitis worldwide, suggesting that VD supplementation may play a role in the improvement of atopic dermatitis.
The aim: This study aims to determine the effectiveness of vitamin D supplementation in atopic dermatitis.
Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and MetaAnalysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2014 and 2024 were taken into account. Several different online reference sources, like Pubmed, SAGEPUB, and ScienceDirect, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.
Results: In the PubMed database, the results of our search brought up 60 articles, whereas the results of our search on SAGEPUB brought up 2017 articles, and our search on ScienceDirect brought up 2023 articles. In the end, we compiled 6 papers, 4 of which came from PubMed, one of which came from ScienceDirect, and one of which came from SagePub. We included six research that met the criteria.
Conclusion: In conclusion, administration of vitamin D supplement can improve atopic dermatitis. It is more advisable to give it for 3 months.
References
Wollenberg A, Werfel T, Ring J, Ott H, Gieler U, Weidinger S. Atopic Dermatitis in Children and Adults Diagnosis and Treatment. Dtsch Arztebl Int. 2023 Mar 31;120(13):224–34.
Frazier W, Bhardwaj N. Atopic Dermatitis: Diagnosis and Treatment. American Academy of Family Physicians. 2020;
Gilaberte Y, Pérez-Gilaberte JB, Poblador-Plou B, Bliek-Bueno K, Gimeno-Miguel A, Prados-Torres A. Prevalence and comorbidity of atopic dermatitis in children: A large-scale population study based on real-world data. J Clin Med. 2020 Jun 1;9(6).
Silverberg JI. Comorbidities and the impact of atopic dermatitis. Vol. 123, Annals of Allergy, Asthma and Immunology. American College of Allergy, Asthma and Immunology; 2019. p. 144–51.
Puar N, Chovatiya R, Paller AS. New treatments in atopic dermatitis. Vol. 126, Annals of Allergy, Asthma and Immunology. American College of Allergy, Asthma and Immunology; 2021. p. 21–31.
Trikamjee T, Comberiati P, D’Auria E, Peroni D, Zuccotti GV. Nutritional Factors in the Prevention of Atopic Dermatitis in Children. Vol. 8, Frontiers in Pediatrics. Frontiers Media S.A.; 2021.
Peroni DG, Piacentini GL, Cametti E, Chinellato I, Boner AL. Correlation between serum 25hydroxyvitamin D levels and severity of atopic dermatitis in children. British Journal of Dermatology. 2011 May;164(5):1078–82.
Chiu YE, Havens PL, Siegel DH, Ali O, Wang T, Holland KE, et al. Serum 25-hydroxyvitamin D concentration does not correlate with atopic dermatitis severity. In: Journal of the American Academy of Dermatology. 2013. p. 40–6.
Aldaghi M, Tehrani H, Karrabi M, Abadi FS, Sahebkar M. The effect of multistrain synbiotic and vitamin D3 supplements on the severity of atopic dermatitis among infants under 1 year of age: a double-blind, randomized clinical trial study. Journal of Dermatological Treatment. 2022;33(2):812–7.
Camargo CA, Ganmaa D, Sidbury R, Erdenedelger K, Radnaakhand N, Khandsuren B. Randomized trial of vitamin D supplementation for winter-related atopic dermatitis in children. Journal of Allergy and Clinical Immunology. 2014 Oct 1;134(4):831-835.e1.
Imoto RR, Uber M, Abagge KT, Lima MN, Rosário NA, de Carvalho VO. Vitamin D supplementation and severity of atopic dermatitis: pre-post assessment. Allergol Immunopathol (Madr). 2021;49(2):66– 71.
Lara-Corrales I, Huang CM, Parkin PC, Rubio-Gomez GA, Posso-De Los Rios CJ, Maguire J, et al. Vitamin D Level and Supplementation in Pediatric Atopic Dermatitis: A Randomized Controlled Trial. J Cutan Med Surg. 2019 Jan 1;23(1):44–9.
Mansour NO, Mohamed AA, Hussein M, Eldemiry E, Daifalla A, Hassanin S, et al. The impact of vitamin D supplementation as an adjuvant therapy on clinical outcomes in patients with severe atopic dermatitis: A randomized controlled trial. Pharmacol Res Perspect. 2020 Dec 1;8(6).
Raj KAP, Handa S, Narang T, Sachdeva N, Mahajan R. Correlation of serum vitamin D levels with severity of pediatric atopic dermatitis and the impact of vitamin D supplementation on treatment outcomes. Journal of Dermatological Treatment. 2022;33(3):1397–400.
LePoidevin LM, Lee DE, Shi VY. A comparison of international management guidelines for atopic dermatitis. Vol. 36, Pediatric Dermatology. Blackwell Publishing Inc.; 2019. p. 36–65.
Reed B, Blaiss MS. The burden of atopic dermatitis. In: Allergy and Asthma Proceedings. OceanSide Publications Inc.; 2018. p. 406–10.
Tsai TF, Rajagopalan M, Chu CY, Encarnacion L, Gerber RA, Santos-Estrella P, et al. Burden of atopic dermatitis in Asia. Vol. 46, Journal of Dermatology. Blackwell Publishing Ltd; 2019. p. 825–34.
Goh MSY, Yun JSW, Su JC. Management of atopic dermatitis: a narrative review. Vol. 216, Medical Journal of Australia. John Wiley and Sons Inc; 2022. p. 587–93.
Laughter MR, Maymone MBC, Mashayekhi S, Arents BWM, Karimkhani C, Langan SM, et al. The global burden of atopic dermatitis: lessons from the Global Burden of Disease Study 1990–2017*. British Journal of Dermatology. 2021 Feb 1;184(2):304–9.
Kim J, Kim BE, Leung DYM. Pathophysiology of atopic dermatitis: Clinical implications. In: Allergy and Asthma Proceedings. OceanSide Publications Inc.; 2019. p. 84–92.
Kulthanan K, Tuchinda P, Nitiyarom R, Chunharas A, Chantaphakul H, Aunhachoke K, et al. Clinical practice guidelines for the diagnosis and management of atopic dermatitis. Vol. 39, Asian Pacific Journal of Allergy and Immunology. Allergy and Immunology Society of Thailand; 2021. p. 145–55.
Fishbein AB, Silverberg JI, Wilson EJ, Ong PY. Update on Atopic Dermatitis: Diagnosis, Severity Assessment, and Treatment Selection. Vol. 8, Journal of Allergy and Clinical Immunology: In Practice. American Academy of Allergy, Asthma and Immunology; 2020. p. 91–101.
Gibbs NK. L-histidine supplementation in adults and young children with atopic dermatitis (eczema). Journal of Nutrition. 2020 Oct 1;150:2576S-2579S.
Reynolds KA, Juhasz MLW, Mesinkovska NA. The role of oral vitamins and supplements in the management of atopic dermatitis: a systematic review. Vol. 58, International Journal of Dermatology. Blackwell Publishing Ltd; 2019. p. 1371–6.
Fenner J, Silverberg NB. Oral supplements in atopic dermatitis. Clin Dermatol. 2018 Sep 1;36(5):653–8.
Huang CM, Lara-Corrales I, Pope E. Effects of Vitamin D levels and supplementation on atopic dermatitis: A systematic review. Vol. 35, Pediatric Dermatology. Blackwell Publishing Inc.; 2018. p. 754–60.
Kanda N, Hoashi T, Saeki H. Nutrition and atopic dermatitis. Journal of Nippon Medical School. 2021;88(3):171–7.
Bouillon R, Manousaki D, Rosen C, Trajanoska K, Rivadeneira F, Richards JB. The health effects of vitamin D supplementation: evidence from human studies. Vol. 18, Nature Reviews Endocrinology. Nature Research; 2022. p. 96–110.
Zhang Y, Fang F, Tang J, Jia L, Feng Y, Xu P, et al. Association between Vitamin D supplementation and mortality: Systematic review and meta-analysis. Vol. 366, The BMJ. BMJ Publishing Group; 2019.
Fu H, Li Y, Huang H, Wang D. Serum Vitamin D Level and Efficacy of Vitamin D Supplementation in Children with Atopic Dermatitis: A Systematic Review and Meta-analysis. Vol. 2022, Computational and Mathematical Methods in Medicine. Hindawi Limited; 2022.
Hattangdi-Haridas SR, Lanham-New SA, Sang Wong WH, Hok Kung Ho M, Darling AL. Vitamin D deficiency and effects of vitamin d supplementation on disease severity in patients with atopic dermatitis: A systematic review and meta-analysis in adults and children. Nutrients. 2019 Aug 1;11(8).
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Licensing
Ninety Nine Publication publishes articles under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This licensing allows for any use of the work, provided the original author(s) and source are credited, thereby facilitating the free exchange and use of research for the advancement of knowledge.
Detailed Licensing Terms
Attribution (BY): Users must give appropriate credit, provide a link to the license, and indicate if changes were made. Users may do so in any reasonable manner, but not in any way that suggests the licensor endorses them or their use.
No Additional Restrictions: Users may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
