THE ANALYSIS STUDY OF EFFECTIVENESS OF VITAMIN D AND CALCIUM SUPPLEMENTATION FOR PREVENTING OF FRACTURES A COMPREHENSIVE SYSTEMATIC REVIEW
DOI:
https://doi.org/10.61841/x7d0x392Keywords:
Vitamin D, calcium, fracture, bone densityAbstract
Background: The interplay between supplementation and other treatments adds complexity to the role of calcium and vitamin D in fracture prevention. This systematic review aims to synthesize existing evidence on the effectiveness of vitamin D and calcium supplementation for fracture prevention based on literatures of the last decade.
Methods: The study followed PRISMA 2020 guidelines, reviewing English-language publications from 2014 to 2024. Editorials, duplicate reviews from the same journal, and papers lacking a DOI were excluded. The literature search was conducted using PubMed, SagePub, SpringerLink, and Google Scholar.
Result: A total of 2,172 articles were initially identified through online databases (PubMed, SagePub, SpringerLink, and Google Scholar). After three rounds of screening, eight relevant studies were selected for full-text analysis.
Conclusion: Vitamin D and calcium supplementation effectively reduce fracture risk, particularly in postmenopausal women and older adults. Adequate intake improves bone mineral density and enhances bone strength, providing significant protection against fractures, especially in those with deficiency.
References
Weaver CM, Alexander DD, Boushey CJ, et al. Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. Osteoporos Int. 2016;27(1):367-376. doi:10.1007/s00198-015-3386-5
Cesareo R, Iozzino M, D’onofrio L, et al. Effectiveness and safety of calcium and vitamin D treatment for postmenopausal osteoporosis. Minerva Endocrinol. 2015;40(3):231-237.
Bristow SM, Gamble GD, Horne AM, Reid IR. Dietary calcium intake and rate of bone loss in men. Br J Nutr. 2017;117(10):1432-1438. doi:10.1017/S0007114517001301
Hiligsmann M, Ben Sedrine W, Bruyere O, Evers SM, Rabenda V, Reginster JY. Cost-effectiveness of vitamin D and calcium supplementation in the treatment of elderly women and men with osteoporosis. Eur J Public Health. 2015;25(1):20-25.
Ethgen O, Hiligsmann M, Burlet N, Reginster JY. Cost-effectiveness of personalized supplementation with vitamin D-rich dairy products in the prevention of osteoporotic fractures. Osteoporos Int. 2016;27(1):301-308. doi:10.1007/s00198-015-3319-3
Bolland MJ, Grey A, Reid IR. Should we prescribe calcium or vitamin D supplements to treat or prevent osteoporosis? Climacteric. 2015;18(sup2):22-31. doi:10.3109/13697137.2015.1098266
Bolland MJ, Avenell A, Grey A. Should adults take vitamin D supplements to prevent disease? BMJ. 2016;355. Accessed January 9, 2025. https://www.bmj.com/content/355/bmj.i6201.short
Chakhtoura M, Chamoun N, Rahme M, Fuleihan GEH. Impact of vitamin D supplementation on falls and fractures—a critical appraisal of the quality of the evidence and an overview of the available guidelines. Bone. 2020;131:115112.
Liu C, Kuang X, Li K, Guo X, Deng Q, Li D. Effects of combined calcium and vitamin D supplementation on osteoporosis in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials. Food Funct. 2020;11(12):10817-10827.
Khaw KT, Stewart AW, Waayer D, et al. Effect of monthly high-dose vitamin D supplementation on falls and non-vertebral fractures: secondary and post-hoc outcomes from the randomised, double-blind, placebo-controlled ViDA trial. Lancet Diabetes Endocrinol. 2017;5(6):438-447.
Buchebner D, McGuigan F, Gerdhem P, Malm J, Ridderstråle M, Åkesson K. Vitamin D insufficiency over 5 years is associated with increased fracture risk—an observational cohort study of elderly women. Osteoporos Int. 2014;25(12):2767-2775. doi:10.1007/s00198-014-2823-1
Swanson CM, Srikanth P, Lee CG, et al. Associations of 25‐Hydroxyvitamin D and 1,25‐Dihydroxyvitamin D With Bone Mineral Density, Bone Mineral Density Change, and Incident Nonvertebral Fracture. J Bone Miner Res. 2015;30(8):1403-1413. doi:10.1002/jbmr.2487
Julian C, Lentjes MAH, Huybrechts I, et al. Fracture Risk in Relation to Serum 25-Hydroxyvitamin D and Physical Activity: Results from the EPIC-Norfolk Cohort Study. PLOS ONE. 2016;11(10):e0164160. doi:10.1371/journal.pone.0164160
Larsen AU, Grimnes G, Jorde R. The effect of high-dose vitamin D3 supplementation on bone mineral density in subjects with prediabetes. Osteoporos Int. 2018;29(1):171-180. doi:10.1007/s00198-017-4222-x
Bristow SM, Bolland MJ, Gamble GD, Leung W, Reid IR. Dietary calcium intake and change in bone mineral density in older adults: a systematic review of longitudinal cohort studies. Eur J Clin Nutr. 2022;76(2):196-205. doi:10.1038/s41430-021-00957-8
Bristow SM, Horne AM, Gamble GD, Mihov B, Stewart A, Reid IR. Dietary Calcium Intake and Bone Loss Over 6 Years in Osteopenic Postmenopausal Women. J Clin Endocrinol Metab. 2019;104(8):3576-3584. doi:10.1210/jc.2019-00111
Porthouse J, Cockayne S, King C, et al. Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care. BMJ. 2015;330(7498):1003. doi:10.1136/bmj.330.7498.1003
Zhao JG, Zeng XT, Wang J, Liu L. Association between calcium or vitamin D supplementation and fracture incidence in community-dwelling older adults: a systematic review and meta-analysis. Jama. 2017;318(24):2466-2482.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Licensing
Ninety Nine Publication publishes articles under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This licensing allows for any use of the work, provided the original author(s) and source are credited, thereby facilitating the free exchange and use of research for the advancement of knowledge.
Detailed Licensing Terms
Attribution (BY): Users must give appropriate credit, provide a link to the license, and indicate if changes were made. Users may do so in any reasonable manner, but not in any way that suggests the licensor endorses them or their use.
No Additional Restrictions: Users may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
