THE COMPREHENSIVE SYSTEMATIC REVIEW OF NEUTROPHIL GELATINASE–ASSOCIATED LIPOCALIN AS A PREDICTOR OF PREECLAMPSIA
DOI:
https://doi.org/10.61841/2ngrc503Keywords:
Neutrophil gelatinase–associated lipocalin (NGAL), pre-eclampsia, eclampsia.Abstract
Background: The use of NGAL for preeclampsia and eclampsia prediction looks appealing, but one has to understand that NGAL levels increase in the state of inflammatory conditions associated with epithelial cell injury like pelvic inflammatory disease, chronic obstructive pulmonary disease, malignancies of breast, lungs, and colon. NGAL is also released from maternalfetal interface and is thought to be released when there is uterine vasoconstriction as happens in preeclampsia.
The aim: This study aims to show about the comprehensive of neutrophil gelatinase-associated lipocalin as a peredictor of pre-eclampsia.
Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and MetaAnalysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2014 and 2024 were taken into account. Several different online reference sources, like Pubmed and SagePub, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.
Result: In the PubMed database, the results of our search brought up 143 articles, whereas the results of our search on SagePub brought up 24 articles. The results of the search conducted for the last year of 2014 yielded a total 70 articles for PubMed and 15 articles for SagePub. The result from title screening, a total 10 articles for PubMed and 12 articles for SagePub. In the end, we compiled a total of 8 papers. We included five research that met the criteria.
Conclusion: The utility of NGAL for diagnosing and assessing the severity of preeclampsia. The increase in NGAL due to preeclampsia is attributed to the presence of endothelium dysfunction and systemic inflammation.
References
Sisti G, Rubin G, Zhou C, Orth T, Schiattarella A. Neutrophil gelatinase–associated lipocalin as a predictor of pre-eclampsia: A systematic review and meta-analysis. Int J Gynecol Obstet. 2023;163(1):63–74.
Tyagi A, Yadav P, Salhotra R, Das S, Singh PK, Garg D. Acute kidney injury in severe preeclamptic patients admitted to intensive care unit: Epidemiology and role of serum neutrophil gelatinase-associated lipocalcin. Indian J Crit Care Med. 2021;25(9):1013–9.
Yolli H, Demir ME, Yildizhan R. Neutrophil gelatinase associated lipocalin-2 (Ngal) levels in preeclampsia. Clin Exp Obstet Gynecol. 2020;47(4):519–23.
Wu P, Van Den Berg C, Alfirevic Z, O’brien S, Röthlisberger M, Baker PN, et al. Early pregnancy biomarkers in pre-eclampsia: A systematic review and meta-analysis. Int J Mol Sci. 2015;16(9):23035–56.
Springer S, Franz M, Worda K, Gorczyca ME, Haslinger P, Worda C. Neutrophil Gelatinase-Associated Lipocalin and Hypertensive Disorders of Pregnancy: A Cohort Study in Twin Pregnancies. J Clin Med. 2022;11(14).
Sachan R, Patel M, Gaurav A, Gangwar R, Sachan P. Correlation of serum neutrophil gelatinase associated lipocalin with disease severity in hypertensive disorders of pregnancy. Adv Biomed Res. 2014;3(1):223.
Ali EA, Hameed BH, Salman AF. The value of neutrophil gelatinase-associated lipocalin and neutrophil / lymphocyte ratio in the diagnosis of preeclampsia and its severity. J Med Investig. 2021;68(3.4):321–5.
Surmiak P, Wojnarowicz O, Szymkowiak M. Malondialdehyde and Neutrophil Gelatinase-Associated Lipocalin as Markers of Oxidative Stress in Small for Gestational Age Newborns from Hypertensive and Preeclamptic Pregnancies. Biomed Res Int. 2022;2022.
Simonazzi G, Capelli I, Curti A, Comai G, Rizzo N, La Manna G. Serum and urinary neutrophil gelatinaseassociated lipocalin monitoring in normal pregnancy versus pregnancies complicated by pre-eclampsia. In Vivo (Brooklyn). 2015;29(1):117–22.
Liu N, Guo YN, Gong LK, Wang BS. Advances in biomarker development and potential application for preeclampsia based on pathogenesis. Eur J Obstet Gynecol Reprod Biol X [Internet]. 2021;9(501). Available from: https://doi.org/10.1016/j.eurox.2020.100119
Wei Y, Li L, Wang F, Fu L, Li Z, Hu Y. Circulating neutrophil gelatinase-associated lipocalin and preeclampsia: a meta-analysis. J Matern Neonatal Med. 2023;36(1).
Zarad A, Shaarawy S, Anwer HF, Elwafa RA, El-Medany S. Renal resistance indices and neutrophil gelatinaseassociated lipocalin for early prediction of acute kidney injury in patients with severe preeclampsia. Egypt J Anaesth [Internet]. 2020;36(1):256–63. Available from: https://doi.org/10.1080/11101849.2020.1842088
Li N, Yang Y, Yue X, Zhang X. Predictive value of Vitamin A and e levels in pre-eclampsia and postpartum kidney injury. Am J Transl Res. 2021;13(4):3427–34.
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