ASSOCIATION COVID-19 AND LIVER INJURY : A SYSTEMATIC REVIEW

Calista Giovani; Theodora Monica Carissa; Claudia Priska Adelin

doi:10.61841/4qab7g74

Authors

Calista Giovani General Practitioner, Samarinda Medika Citra General Hospital, Samarinda, Indonesia Author
Theodora Monica Carissa General Practitioner, Wava Husada General Hospital, Kepanjen, Malang Regency, Indonesia Author
Claudia Priska Adelin General Practitioner, Rumah Sehat UGM Primary Clinic, Special Region of Yogyakarta, Indonesia Author

DOI:

https://doi.org/10.61841/4qab7g74

Keywords:

COVID-19, Liver injury, SARS-CoV-2, Liver enzyms.

Abstract

Background: Most COVID-19 patients present with typical respiratory symptoms (i.e., cough, dyspnea) and fever. However, abnormal liver function is often developed in patients with COVID-19, and liver injury has been related with severe disease. Liver damage ranges from mild asymptomatic elevation of liver enzymes to severe liver injury, while a few cases of acute liver failure have also been reported.

The aim: This study aims to show association COVID-19 and liver injury.

Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and MetaAnalysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2013 and 2023 were taken into account. Several different online reference sources, like Pubmed and SagePub, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.

Result: In the PubMed database, the results of our search brought up 44 articles, whereas the results of our search on SagePub brought up 334 articles. The results of the search conducted for the last year of 2013 yielded a total 7 articles for PubMed and 111 articles for SagePub. The result from title screening, a total 4 articles for PubMed and 46 articles for SagePub. In the end, we compiled a total of 10 papers. We included five research that met the criteria.

Conclusion: COVID-19-associated liver injury is caused by the cumulative effects of multiple factors, including hepatotropic SARS-CoV-2, drug-induced liver injury, hypoxic reperfusion, immune stress and inflammatory factor storms.

References

Altaf A, Abbas Z, Mandviwalla HA, Qadeer MA, Siyal M, Tariq M, et al. Severe COVID-19 Associated With Liver Injury in Patients Without Preexisting Liver Disease. Cureus. 2021;13(4):4–11.

Krishnamoorthy Y, Karunakaran M, Ganesh K, Hariharan VS. Association between acute liver injury & severity and mortality of COVID-19 patients: A systematic review and meta-analysis. Heliyon [Internet]. 2023;9(9):e20338. Available from: https://doi.org/10.1016/j.heliyon.2023.e20338

Qi RB, Wu ZH. Association between COVID-19 and chronic liver disease: Mechanism, diagnosis, damage, and treatment. World J Virol. 2023;12(1):22–9.

Papagiouvanni I, Kotoulas SC, Pataka A, Spyratos DG, Porpodis K, Boutou AK, et al. COVID-19 and liver injury: An ongoing challenge. World J Gastroenterol. 2023;29(2):257–71.

Helou M, Nasr J, El Osta N, Jabbour E, Husni R. Liver manifestations in COVID-19 patients: A review article. World J Clin Cases. 2023;11(10):2189–200.

Rajbhandari B, Pant S, Hamal AB, Thapa A, Shrestha A, Shrestha S, et al. Liver injury in COVID-19: prevalence and its associated factors in Nepal – A retrospective cross-sectional study. Ann Med Surg. 2023;85(6):2522–7.

Phipps MM, Barraza LH, LaSota ED, Sobieszczyk ME, Pereira MR, Zheng EX, et al. Acute Liver Injury in COVID-19: Prevalence and Association with Clinical Outcomes in a Large U.S. Cohort. Hepatology. 2020;72(3):807–17.

Chen F, Chen W, Chen J, Xu D, Xie W, Wang X, et al. Clinical features and risk factors of COVID-19-associated liver injury and function: A retrospective analysis of 830 cases. Ann Hepatol. 2021;21.

Salık F, Uzundere O, Bıçak M, Akelma H, Akgündüz M, Korhan Z, et al. Liver function as a predictor of mortality in COVID-19: A retrospective study. Ann Hepatol. 2021;26.

Chela HK, Tallon EM, Baskett W, Gangu K, Tahan V, Shyu CR, et al. Liver injury on admission linked to worse outcomes in COVID-19: an analysis of 14,138 patients. Transl Gastroenterol Hepatol. 2023;8(July 2021).

Ali N. Relationship Between COVID-19 Infection and Liver Injury: A Review of Recent Data. Front Med. 2020;7(July):1–6.

Christa L. Walker, Igor Rudan, Li Liu HN. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. Ann Oncol. 2020;7(May):19-21,.

Yang R, Feng J, Wan H, Zeng X, Ji P, Zhang J. Liver injury associated with the severity of COVID-19: A metaanalysis. Front Public Heal. 2023;11.

Elemam NM, Talaat IM, Maghazachi AA. Liver Injury Associated with COVID-19 Infection : Pathogenesis , Histopathology , Prognosis , and Treatment. 2023;

Zhao SW, Li YM, Li YL, Su C. Liver injury in COVID-19: Clinical features, potential mechanisms, risk factors and clinical treatments. World J Gastroenterol. 2023;29(2):241–56.

Li P, Liu Y, Cheng Z, Yu X, Li Y. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19 . The COVID-19 resource centre is hosted on Elsevier Connect , the company ’ s public news and information website . Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre including this research content - immediately available in PubMed Central and other publicly funded repositories , such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source . These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active . COVID-19-associated liver injury : Clinical characteristics , pathophysiological mechanisms and treatment management. 2020;(January).