THE ANALYSIS STUDY OF INTERVENTIONS FOR DRY EYES: A COMPREHENSIVE SYSTEMATIC REVIEW

Authors

  • Putri Rosalina Tamzil General Practitioner, Oto Iskandar Di Nata Regional General Hospital, Soreang, Indonesia Author
  • Diantinia Opthalmology Consultant, Oto Iskandar Di Nata Regional General Hospital, Soreang, Indonesia Author
  • Ratna Anten Opthalmology Consultant, Oto Iskandar Di Nata Regional General Hospital, Soreang, Indonesia Author

DOI:

https://doi.org/10.61841/hamfeh88

Keywords:

Cyclosporine, dietary supplement, dry eyes syndrome, intense pulse light, NOV03, perfluorohexyloctane, tear film lipid layer

Abstract

Introduction: Dry eye disease (DED) results from dysregulated ocular inflammation, causingpersistent ocular surface dysfunction, with a global surge in prevalence, especially among children andadolescents, due to increased technology use. Beyond significant ocular morbidity, DED's association with systemic autoimmune disorders, impact on quality of life, and links to psychological and sleep disorders underscore its extensive repercussions. This systematic review aims to comprehensively explore an integrated approach to managing DED, emphasizing preventive and promotive strategies across various levels of healthcare.

Method: The researchers in this study followed the 2020 PreferredReporting Items for Systematic Review and MetaAnalysis (PRISMA) guidelines to ensure that their work met the required standards. This was done to ensure the precision and reliability of the conclusionsderived from the research.

Result: This systematic review investigated final 15 articles. After looking at the titles and summaries, we found 6 papers that fit our criteria. At first, we excluded several articlesbecause they were written in review style and case reports. But after reading the full papers carefully, we included four papers inour final analysis. These papers included a retrospective observational study,prospective study, and double-blind, randomized, placebo-controlled trial, and prospective interventional pilot study.

Conclusion: In summary, a study suggests that OPT-IPL (Optilight Intense Pulse Light) treatment enhances tear film lipid layer (TFLL) and improves signs and symptoms of dryeye disease (DED) by enhancing meibomian gland function. The phase 3 trial with NOV03 provides compelling evidence of reduced DED signs and symptoms over 8 weeks, demonstrating statistical andclinical significance, with good tolerability. Additionally, the ESSENCE-2 trial highlights the efficacyof a water-free cyclosporine solution in improving ocular surface staining associated with DED, showcasing potential advantages over existing therapies. Our study revealed promising and safe outcomes for dietary supplementation, which preserved tear production in a rat dry eye model and showed significant improvements in both objective parameters and subjective dry eye symptoms. However, further data is needed to validate its widespread use as a common intervention.

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Published

2024-06-12

How to Cite

Tamzil, P. R., Diantinia, & Anten, R. (2024). THE ANALYSIS STUDY OF INTERVENTIONS FOR DRY EYES: A COMPREHENSIVE SYSTEMATIC REVIEW. Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 10(6), 81-87. https://doi.org/10.61841/hamfeh88

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