LEVEL OF ALBUMIN IN MALARIA AND HIV CO INFECTED PREGNANT WOMEN, ATTENDING THE ANTENATAL CLINIC OF NNAMDI AZIKIWE UNIVERSITY TEACHING HOSPITAL, NNEWI, SOUTH EASTERN NIGERIA
DOI:
https://doi.org/10.61841/c8ykyc17Abstract
The purpose of the study was to measure the amount of albumin in pregnant HIV-positive malaria-infected women. Participants in the study were 18 to 40 (36.98 + 5.49) years old, HIV stage 1 and 2 seropositive pregnant women. 80 HIV-positive pregnant women with 40 co-infected with malaria and 80 HIV-negative pregnant women with 40 coinfected with malaria comprised the participant groups. Blood samples were obtained from the subjects for malaria parasite identification using the thick and thin film methods, and HIV status determination using the immunochromatographic approach. The bromocresol green albumin binding method was used to measure the amount of albumin, and the resultant solution was measured spectrophotometrically at 628 nm. In all cases, there was a statistically significant difference in albumin levels between the HIV seronegative group with and without malaria infection (p<0.05) and HIV seropositive group with malaria infection. The mean albumin level of HIV-positive pregnant women who have malaria infection was statistically higher than that of HIV-positive pregnant women who do not have malaria but statistically lower than those of HIV-negative pregnant women with and without malaria infection. The study suggests that pregnant HIV-positive women do not experience a decrease in albumin levels because of malaria infection.
References
Adu-Gyasi D, Adams M, Amoako S, Mahama E, Nsoh M, Amenga-Etego S, Baiden F, Asante KP, Newton S, Owusu-Agyei S. Estimating malaria parasite density: assumed white blood cell count of 10,000/μl of blood is appropriate measure in Central Ghana. Malar J. 2012 Jul 23; 11:238. doi: 10.1186/1475-2875-11-238. PMID: 22823983; PMCID: PMC3411500.
Busher J.T (1990). Serum Albumin and Globulin; In Walker HK, Hall WD, Hurst JW (eds.). Clinical methods: a. the history, physical, and laboratory examinations (3rd ed.) Chapter 101: Boston: Butterworths. ISBN 9780409900774.
Dao C.N, Peters P.J, Kiarie J.N (2011). Hyponatraemia, hypochloreamia and hypoalbuminaemia predict an increased risk of mortality during the first year of antiretroviral therapy among HIV infected Zambian and Kenyan women. AIDS Res Hum Retroviruses. 27:1149-55.
Goselle O.N., Onwuliri C.O.E., Onwuliri V.A (2007). Malaria and the Effect of Malaria Parasitaemia on Albumin Level Among HIV/AIDS-Patients in Jos, Nigeria. Journal of Medical Sciences, 7, 1187-1191.
Haefliger D.N, Moskaitis J.E, Schoenberg D.R, Wahli W (1989). Amphibian albumins as members of the albumin, alpha-fetoprotein, vitamin D-binding protein multigene family. Journal of Molecular Evolution. 29 (4), 344–54.
He X.M, Carter D.C (1992). Atomic structure and chemistry of human serum albumin. Nature. 358 (6383), 209– 215. Bibcode: Natur.358.209. doi:10.1038/358209a0.PMID 1630489. S2CID 4353741.
Jean M Mcginlay and Payne R.B (1988). Serum albumin by dye-binding: bromocresol green Or bromocresol purple? The case for conservatism. Ann Clin Biochem 25:417-421.
Kublin J.G, Patnaik P, Jere C.S (2005). Effect of Plasmodium falciparum malaria on concentration of HIV-1RNA in the blood of adults in rural Malawi: a prospective cohort study. Lancet. 365 (9455),233–240.
Li S, Cao Y, Geng F (2017). Genome-Wide Identification and Comparative Analysis of Albumin Family in Vertebrates. Evolutionary Bioinformatics Online. 13 (11), 7693-7716.
Mutlu E.A, Keshavarzian A, Mutlu G.M. Hyperalbuminemia and elevated transaminases associated with highprotein diet. Scandinavian Journal of Gastroenterology. 41 (6):759–60.
Osuji F.N, Onyenekwe C.C, Ifeanyichukwu M, Ahaneku J.E, Ezeani M, Ezeugwunne I.P (2012) Antioxidant activity in HIV and malaria co-infected subjects. Asian Pac J Trop Med. 7,45-50.
UNAIDS (2007). AIDS epidemic update, Geneva, Switzerland, USSAID (2022). Prevalence of HIV in Nigeria.
World Health Organization (2007), HIV Clinical Trials. 8(4), 246–53.
World Health Organization (2008). World Malaria Report 2008, WHO Press, Geneva, Switzerland.
World Health Organization (2008). HIV/AIDS in the South-East Asia region. March. New Delhi, WHO, Regional Office for South-East Asia.
World Health Organization (2007), United Natons Programme on AIDS. Towards universal access: scaling up priority HIV/AIDS interventions in the health sector: progress report. April,Geneva . ISBN 978. 924595391.
World Health Organization (2010). Recommendations on the diagnosis of HIV infection in infants and children. Geneva, WHO.
World Health Organization (2012). Couples HIV testing and counselling including antiretroviral. therapy for treatment and prevention in serodiscordant couples. Geneva.
World Health Organization (2020), World Malaria Report. Geneva.
Yu, Y. T., Liu, J., Hu, B., Wang, R. L., Yang, X. H., Shang, X. L., Chen, D. C (2021). Expert consensus on the use of human serum albumin in critically ill patients. Chinese medical journal, 134(14),1639-1645.
Zakama, A.K., Ozarslan, N. Gaw, S.L (2020). Placental Malaria. Curr Trop Med Rep 7, 162–171 a. https://doi.org/10.1007/s40475-020-00213-2
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Licensing
Ninety Nine Publication publishes articles under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This licensing allows for any use of the work, provided the original author(s) and source are credited, thereby facilitating the free exchange and use of research for the advancement of knowledge.
Detailed Licensing Terms
Attribution (BY): Users must give appropriate credit, provide a link to the license, and indicate if changes were made. Users may do so in any reasonable manner, but not in any way that suggests the licensor endorses them or their use.
No Additional Restrictions: Users may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
