ASSOCATION BETWEEN PSORIASIS AND CELIAC DISEASE: A SYSTEMATIC REVIEW
DOI:
https://doi.org/10.53555/k7fj0w30Keywords:
Autoimmune, Celiac disease, Gluten, PsoriasisAbstract
Psoriasis is an inflammatory illness that affects the skin and is characterised by the formation of erythematous and scaly plaques. Psoriasis is a chronic condition. Psoriasis vulgaris, often known as plaque psoriasis, is the most common form of psoriasis; however, there are many other types of psoriasis as well. Psoriasis vulgaris is the most common form of psoriasis. The bulk of the research that was done to study whether or not celiac disease and psoriasis could have a connection was flawed or biased in some way, which resulted in conclusions that could not be considered definitive. These flaws or biases included a small sample size, a lack of controls, a low accuracy of serological methods used to screen for celiac disease (i.e. anti-gliadin antibodies, AGAs), and the setting, including the design as single-centre studies. All of these issues contributed to the conclusion that the study was flawed or biased. Despite the fact that there is a connection between the two disorders, the physiopathologic mechanisms that are at the root of the connection between psoriasis and CD have not been fully explored. The presence of shared genes (at-risk HLA haplotypes), which are frequently taken into consideration when attempting to explain the increased incidence of CD in a number of autoimmune illnesses, could be present in people who have psoriasis, according to our working hypothesis. Psoriasis is a chronic inflammatory skin condition that can affect any part of the body. Although the results of the link between psoriasis and celiac disease based on the research that was conducted in 2010 are inconsistent, newer studies and studies that were conducted before 2010 provide evidence that there is a connection between the two conditions. Celiac disease is an autoimmune disorder that affects the small intestine and can cause psoriasis.
References
Christophers E. Psoriasis− epidemiology and clinical spectrum. Clin Exp Dermatol. 2001;26(4):314–20.
Sarkar R, Chugh S, Bansal S. General measures and quality of life issues in psoriasis. Indian Dermatol Online J. 2016;7(6):481–8.
Ahlehoff O, Gislason GH, Jørgensen CH, Lindhardsen J, Charlot M, Olesen JB, et al. Psoriasis and risk of atrial fibrillation and ischaemic stroke: a Danish Nationwide Cohort Study. Eur Heart J. Agustus 2012;33(16):2054– 64.
Kokpol C, Aekplakorn W, Rajatanavin N. Prevalence and characteristics of metabolic syndrome in South-East Asian psoriatic patients: a case-control study. J Dermatol. Oktober2014;41(10):898–902.
Ungprasert P, Sanguankeo A, Upala S, Suksaranjit P. Psoriasis and risk of venous thromboembolism: a systematic review and meta-analysis. QJM. Oktober 2014;107(10):793–7.
Marks J, Shuster S. Psoriatic enteropathy. Arch Dermatol. Juni 1971;103(6):676–8.
Fauci AS, Jameson JL, Kasper D, et al. Harrison’s Principles of Internal Medicine 19th Edition. New York: McGraw-Hill Education; 2018.
Birkenfeld S, Dreiher J, Weitzman D, Cohen AD. Coeliac disease associated with psoriasis. Br J Dermatol. Desember 2009;161(6):1331–4.
Ojetti V, Aguilar Sanchez J, Guerriero C, Fossati B, Capizzi R, De Simone C, et al. High prevalence of celiac disease in psoriasis. Vol. 98, The American journal of gastroenterology. United States; 2003. hal.2574–5.
Montesu MA, Dessì-Fulgheri C, Pattaro C, Ventura V, Satta R, Cottoni F. Association between psoriasis and coeliac disease? A case-control study. Vol. 91, Acta dermato-venereologica. Sweden; 2011. hal.92–3.
De Bastiani R, Gabrielli M, Lora L, Napoli L, Tosetti C, Pirrotta E, et al. Association between coeliac disease and psoriasis: Italian primary care multicentre study. Dermatology. 2015;230(2):156–60.
Ford AR, Siegel M, Bagel J, Cordoro KM, Garg A, Gottlieb A, et al. Dietary Recommendations for Adults With
Psoriasis or Psoriatic Arthritis From the Medical Board of the National Psoriasis Foundation: A Systematic Review. JAMA dermatology. Agustus 2018;154(8):934–50.
Afifi L, Danesh MJ, Lee KM, Beroukhim K, Farahnik B, Ahn RS, et al. Dietary behaviors in psoriasis: patientreported outcomes from a US national survey. Dermatol Ther (Heidelb). 2017;7(2):227–42.
Passali M, Josefsen K, Frederiksen JL, Antvorskov JC. Current evidence on the efficacy of gluten-free diets in multiple sclerosis, psoriasis, type 1 diabetes and autoimmune thyroid diseases. Nutrients.2020;12(8):2316.
Persechino F, Galli G, Persechino S, Valitutti F, Zenzeri L, Mauro A, et al. Skin Manifestations and Coeliac Disease in Paediatric Population. Nutrients. 2021;13(10):3611.
Wu AG, Weinberg JM. The impact of diet on psoriasis. Cutis. 2019;104(2S):7–10.
Yu XB, Uhde M, Green PH, Alaedini A. Autoantibodies in the extraintestinal manifestations of celiac disease. Nutrients. 2018;10(8):1123.
Pearlman M, Casey L. Who should be gluten-free? A review for the general practitioner. Med Clin. 2019;103(1):89–99.
Shewry PR. Wheat. J Exp Bot. 2009;60(6):1537–53.
Scherf KA, Koehler P, Wieser H. Gluten and wheat sensitivities–an overview. J Cereal Sci. 2016;67:2–11.
Schalk K, Lexhaller B, Koehler P, Scherf KA. Isolation and characterization of gluten protein types from wheat, rye, barley and oats for use as reference materials. PLoS One.2017;12(2):e0172819.
Vici G, Camilletti D, Polzonetti V. Possible role of vitamin D in celiac disease onset. Nutrients. 2020;12(4):1051.
Acharya P, Mathur M. Association between psoriasis and celiac disease: A systematic review and meta-analysis. J Am Acad Dermatol [Internet]. 1 Juni 2020;82(6):1376–85. Tersedia pada: https://doi.org/10.1016/j.jaad.2019.11.039
Aletaha D, Epstein AJ, Skup M, Zueger P, Garg V, Panaccione R. Risk of developing additional immunemediated manifestations: a retrospective matched cohort study. Adv Ther. 2019;36(7):1672–83.
Ludvigsson JF, Lindelöf B, Zingone F, Ciacci C. Psoriasis in a nationwide cohort study of patients with celiac disease. J Invest Dermatol. 2011;131(10):2010–6.
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