ANTIOXIDANT THERAPY IN THE ELDERLY WITH TINNITUS: SYSTEMATICS REVIEW

Authors

  • Febrian Syahputra Faculty of Medicine, University of Malahayati, Indonesia Author

DOI:

https://doi.org/10.53555/nnmhs.v9i5.1688

Keywords:

Antioxidant, Elderly, Hearing, Inflammation, Tinnitus

Abstract

Tinnitus is one of the most prevalent and annoying disorders that affect the ear and the auditory system. It is one of the most important symptoms in neurootology, along with hearing loss, vertigo, dizziness, and nausea. It can cause a variety of somatic and psychological disorders that interfere with a person's quality of life. There is a correlation between oxidative stress and tinnitus. Hair cell apoptosis, cochlear degeneration, alterations to supporting structures and stria vascularis, changes to the nerve fibers of the acoustic nerve, irregular neuronal activity in the auditory pathway, and malfunction in the central cortex are all possible outcomes of oxidative stress. Animal models of aging, noise damage, and ototoxicity have been used to investigate the relationship between oxidative stress and the death of hair cells. Antioxidants are substances that can take on a wide variety of chemical structures, but they are categorized as a single class because they share the ability to neutralize the effects of highly reactive and potentially damaging free radicals. These radicals are produced when foods undergo the necessary oxidation reactions that are a natural part of the digestion process. Antioxidant supplementation with vitamins, minerals, phytochemicals, and alpha-lipoic acid (ALA) might have therapeutic effects on tinnitus by reducing the subjective discomfort and the level of severity caused by the ringing in the ears.

References

Chang NC, Dai CY, Lin WY, Yang HL, Wang HM, Chien CY, et al. Prevalence of persistent tinnitus and dizziness in an elderly population in southern Taiwan. J Int Adv Otol. 2019;15(1):99.

Swain SK. Impact of tinnitus on quality of life: a review. Int J Adv Med. 2021;8(7):1006–10.

Laybauer Silveira A, Hundertmarck Lessa A, Schmidt Rosito LP, Ribeiro Teixeira A, Domingos dos Santos N. Tinnitus in adult and elderly: comparative analysis considering the time and location of the symptom. Int Arch Otorhinolaryngol. 2022;26.

Malesci R, Brigato F, Di Cesare T, Del Vecchio V, Laria C, De Corso E, et al. Tinnitus and Neuropsychological Dysfunction in the Elderly: A Systematic Review on Possible Links. J Clin Med. 2021;10(9):1881.

Baguley D, McFerran D, Hall D. Tinnitus. Lancet. 2013;382(9904):1600–7.

Ciorba A, Bianchini C, Pastore A, Mazzoli M. Pathogenesis of tinnitus: any role for oxidative stress? J Int Adv Otol. 2013;9(2):249.

Gonzalez-Gonzalez S. The role of mitochondrial oxidative stress in hearing loss. Neurol Disord Ther. 2017;1(4):1– 5.

Celik M, Koyuncu İ. A Comprehensive Study of Oxidative Stress in Tinnitus Patients. Indian J Otolaryngol head neck Surg Off Publ Assoc Otolaryngol India. 2018 Dec;70(4):521–6.

Ekinci A, Kamasak K. Evaluation of serum prolidase enzyme activity and oxidative stress in patients with tinnitus. Braz J Otorhinolaryngol. 2020;86(4):405–10.

Petridou AI, Zagora ET, Petridis P, Korres GS, Gazouli M, Xenelis I, et al. The Effect of Antioxidant Supplementation in Patients with Tinnitus and Normal Hearing or Hearing Loss: A Randomized, Double-Blind, Placebo Controlled Trial. Nutrients. 2019 Dec;11(12).

Radunz CL, Okuyama CE, Branco-Barreiro FCA, Pereira RMS, Diniz SN. Clinical randomized trial study of hearing aids effectiveness in association with Ginkgo biloba extract (EGb 761) on tinnitus improvement. Braz J Otorhinolaryngol. 2020;86(6):734–42.

Procházková K, Šejna I, Skutil J, Hahn A. Ginkgo biloba extract EGb 761(®) versus pentoxifylline in chronic tinnitus: a randomized, double-blind clinical trial. Int J Clin Pharm. 2018 Oct;40(5):1335–41.

Huang Y-C, Wu C-T, Chen M-F, Kuo Y-H, Li J-M, Shi C-S. Intracavernous Injection of Autologous Platelet-Rich Plasma Ameliorates Hyperlipidemia-Associated Erectile Dysfunction in a Rat Model. Sex Med. 2021 Apr;9(2):100317.

Karafakioğlu YS. Effects of α lipoic acid on noise induced oxidative stress in rats. Saudi J Biol Sci. 2019;26(5):989– 94.

Xiong H, Ou Y, Xu Y, Huang Q, Pang J, Lai L, et al. Resveratrol Promotes Recovery of Hearing following Intense Noise Exposure by Enhancing Cochlear SIRT1 Activity. Audiol Neurootol. 2017;22(4–5):303–10.

Gulcin İ. Antioxidants and antioxidant methods: An updated overview. Arch Toxicol. 2020;94(3):651–715.

Luetzenberg FS, Babu S, Seidman MD. Alternative treatments of tinnitus: alternative medicine. Otolaryngol Clin North Am. 2020;53(4):637–50.

Santos-Sánchez NF, Salas-Coronado R, Villanueva-Cañongo C, Hernández-Carlos B. Antioxidant compounds and their antioxidant mechanism. Antioxidants. 2019;10:1–29.

Noack V, Pak K, Jalota R, Kurabi A, Ryan AF. An Antioxidant Screen Identifies Candidates for Protection of Cochlear Hair Cells from Gentamicin Toxicity. Front Cell Neurosci. 2017;11:242.

Liu D, Hu Y, Wang D, Han H, Wang Y, Wang X, et al. Herbal medicines in the treatment of tinnitus: An updated review. Front Pharmacol. 2023;13:5436.

Sies H. Oxidative stress: Concept and some practical aspects. Antioxidants. 2020;9(9):852.

Chen H-L, Tan C-T, Wu C-C, Liu T-C. Effects of Diet and Lifestyle on Audio-Vestibular Dysfunction in the Elderly: A Literature Review. Nutrients. 2022 Nov;14(22).

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Published

2023-05-19

How to Cite

Syahputra, F. (2023). ANTIOXIDANT THERAPY IN THE ELDERLY WITH TINNITUS: SYSTEMATICS REVIEW. Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 9(5), 81-86. https://doi.org/10.53555/nnmhs.v9i5.1688

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