THE ANALYSIS STUDY OF ASSOCIATION OF PHARMACOLOGICAL TREATMENTS WITH LONG-TERM PAIN CONTROL IN PATIENTS WITH KNEE OSTEOARTHRITIS: A COMPREHENSIVE SYSTEMATIC REVIEW
DOI:
https://doi.org/10.61841/jsg5sb93Keywords:
KOA, knee, joint, CHM, PRPAbstract
Background: Knee osteoarthritis (KOA) is a degenerative joint disease affecting 10% of males and 13% of women aged 60 or older. It causes joint discomfort, weakened muscles, and physical limitations. Treatment consists of surgical and non-surgical approaches, with knee arthroplasty being the most successful. Non-regenerative therapies like ozone, corticosteroids, and prolotherapy are popular but short-lived. Chinese herbal medicine (CHM) is widely used to treat KOA, targeting specific biological processes associated with the disease.
Methods: Following PRISMA 2020 guidelines, this systematic review concentrated on full-text English literature published between 2014 and 2024. Editorials and review articles that appeared in the same journal as the submission were not accepted without a DOI. A number of websites, including ScienceDirect, PubMed, and SagePub, were utilized to gather the literature.
Result: The study looked at more than 200 publications using reputable sources including Science Direct, SagePub, and PubMed. After it was decided that eight publications needed greater investigation, a more extensive review of the entire literature was carried out.
Conclusion: Knee osteoarthritis is a common disease affecting middle-aged and elderly individuals. Platelet-rich plasma (PRP) injections, combined with hyaluronic acid, can alleviate knee pain and improve function. However, the efficacy varies depending on the formulation. Traditional Chinese herbal medicine has shown potential in treating KOA, but its effectiveness and safety remain debatable due to limited clinical trials and methodological rigor.
References
Crowley, J. L., & Soti, V. (2023). Platelet-Rich Plasma Therapy: An Effective Approach for Managing Knee Osteoarthritis. Cureus, 15(12), e50774. https://doi.org/10.7759/cureus.50774
Hamood, R., Tirosh, M., Fallach, N., Chodick, G., Eisenberg, E., & Lubovsky, O. (2021). Prevalence and Incidence of Osteoarthritis: A Population-Based Retrospective Cohort Study. Journal of clinical medicine, 10(18), 4282. https://doi.org/10.3390/jcm10184282
Sen R, Hurley JA. Osteoarthritis. [Updated 2023 Feb 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482326/
Wu, Z., Zhou, R., Zhu, Y., Zeng, Z., Ye, Z., Wang, Z., Liu, W., & Xu, X. (2022). Self-Management for Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Pain research & management, 2022, 2681240. https://doi.org/10.1155/2022/2681240
Arslan, I. G., Damen, J., de Wilde, M., van den Driest, J. J., Bindels, P. J. E., van der Lei, J., Schiphof, D., & Bierma-Zeinstra, S. M. A. (2022). Incidence and Prevalence of Knee Osteoarthritis Using Codified and Narrative Data From Electronic Health Records: A Population-Based Study. Arthritis care & research, 74(6), 937–944. https://doi.org/10.1002/acr.24861
Cram, P., Lu, X., Kates, S. L., Singh, J. A., Li, Y., & Wolf, B. R. (2012). Total knee arthroplasty volume, utilization, and outcomes among Medicare beneficiaries, 1991-2010. JAMA, 308(12), 1227–1236. https://doi.org/10.1001/2012.jama.11153
Pradelli, L., Sinigaglia, T., Migliore, A., Checchia, G. A., Franceschi, F., Frediani, B., Iannone, F., & Romanini, E. (2021). Non-Surgical Treatment of Knee Osteoarthritis: Multidisciplinary Italian Consensus on Best Practice. Therapeutics and clinical risk management, 17, 507–530. https://doi.org/10.2147/TCRM.S288196
Michael, J. W., Schlüter-Brust, K. U., & Eysel, P. (2010). The epidemiology, etiology, diagnosis, and treatment of osteoarthritis of the knee. Deutsches Arzteblatt international, 107(9), 152–162. https://doi.org/10.3238/arztebl.2010.0152
Wee, T. C., Neo, E. J. R., & Tan, Y. L. (2021). Dextrose prolotherapy in knee osteoarthritis: A systematic review and meta-analysis. Journal of clinical orthopaedics and trauma, 19, 108–117. https://doi.org/10.1016/j.jcot.2021.05.015
Lin, Z., Zheng, J., Chen, M., Chen, J., & Lin, J. (2022). The Efficacy and Safety of Chinese Herbal Medicine in the Treatment of Knee Osteoarthritis: An Updated Systematic Review and Meta-Analysis of 56 Randomized
Controlled Trials. Oxidative medicine and cellular longevity, 2022, 6887988. https://doi.org/10.1155/2022/6887988
Lao, L., Hochberg, M., Lee, D. Y. W., Gilpin, A. M. K., Fong, H. H. S., Langenberg, P., Chen, K., Li, E. K., Tam, L. S., & Berman, B. (2015). Huo-Luo-Xiao-Ling (HLXL)-Dan, a Traditional Chinese Medicine, for patients with osteoarthritis of the knee: a multi-site, randomized, double-blind, placebo-controlled phase II clinical trial. Osteoarthritis and cartilage, 23(12), 2102–2108. https://doi.org/10.1016/j.joca.2015.06.007
Maroon, J. C., Bost, J. W., & Maroon, A. (2010). Natural anti-inflammatory agents for pain relief. Surgical neurology international, 1, 80. https://doi.org/10.4103/2152-7806.73804
Pan, L., Zhou, J., Zhu, H., Wang, W., Zhang, M., Tian, X., Lu, J., & Zeng, M. (2014). Study on integrated pharmacokinetics of gardenia acid and geniposide: time-antioxidant efficacy after oral administration of Huanglian-Zhizi couplet medicine from Huang-Lian-Jie-Du-Tang in MCAO rats. The American journal of Chinese medicine, 42(2), 393–407. https://doi.org/10.1142/S0192415X14500268
Zhao, J., Huang, H., Liang, G., Zeng, L. F., Yang, W., & Liu, J. (2020). Effects and safety of the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) in the treatment of knee osteoarthritis: a systematic review and meta-analysis. BMC musculoskeletal disorders, 21(1), 224. https://doi.org/10.1186/s12891-020-03262-w
Huang, Z., Mao, X., Chen, J., He, J., Shi, S., Gui, M., Gao, H., & Hong, Z. (2022). The Efficacy and Safety of Zhengqing Fengtongning for Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Evidence-based complementary and alternative medicine : eCAM, 2022, 2768444. https://doi.org/10.1155/2022/2768444
Zhao, J., Yang, W., Liang, G., Luo, M., Pan, J., Liu, J., & Zeng, L. (2022). The efficacy and safety of Jinwu Gutong capsule in the treatment of knee osteoarthritis: A meta-analysis of randomized controlled trials. Journal of ethnopharmacology, 293, 115247. https://doi.org/10.1016/j.jep.2022.115247
Campbell, C. M., Mun, C. J., Hamilton, K. R., Bergeria, C. L., Huhn, A. S., Speed, T. J., Vandrey, R., & Dunn, K. E. (2023). Within-subject, double-blind, randomized, placebo-controlled evaluation of combining the cannabinoid dronabinol and the opioid hydromorphone in adults with chronic pain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 48(11), 1630–1638. https://doi.org/10.1038/s41386-023-01597-1
Mintarjo, J. A., Poerwanto, E., & Tedyanto, E. H. (2023). Current Non-surgical Management of Knee Osteoarthritis. Cureus, 15(6), e40966. https://doi.org/10.7759/cureus.40966
Zeng, F., Wang, K., Duan, H., Xu, X. T., Kuang, G. Y., & Lu, M. (2023). Diacerein versus non-steroidal antiinflammatory drugs in the treatment of knee osteoarthritis: a meta-analysis. Journal of orthopaedic surgery and research, 18(1), 308. https://doi.org/10.1186/s13018-023-03786-6
Cowan, K. J., Kleinschmidt-Dörr, K., Gigout, A., Moreau, F., Kraines, J., Townsend, R., Dolgos, H., & DeMartino, J. (2020). Translational strategies in drug development for knee osteoarthritis. Drug discovery today, 25(6), 1054–1064. https://doi.org/10.1016/j.drudis.2020.03.015
Cao, P., Li, Y., Tang, Y., Ding, C., & Hunter, D. J. (2020). Pharmacotherapy for knee osteoarthritis: current and emerging therapies. Expert Opinion on Pharmacotherapy, 21(7), 797–809. https://doi.org/10.1080/14656566.2020.1732924
Gupta, S., Paliczak, A., & Delgado, D. (2021). Evidence-based indications of platelet-rich plasma therapy. Expert review of hematology, 14(1), 97–108. https://doi.org/10.1080/17474086.2021.1860002
Babalonis, S., Lofwall, M. R., Sloan, P. A., Nuzzo, P. A., Fanucchi, L. C., & Walsh, S. L. (2019). Cannabinoid modulation of opioid analgesia and subjective drug effects in healthy humans. Psychopharmacology, 236(11), 3341–3352. https://doi.org/10.1007/s00213-019-05293-1
Nielsen, S., Picco, L., Murnion, B., Winters, B., Matheson, J., Graham, M., Campbell, G., Parvaresh, L., Khor, K. E., Betz-Stablein, B., Farrell, M., Lintzeris, N., & Le Foll, B. (2022). Opioid-sparing effect of cannabinoids for analgesia: an updated systematic review and meta-analysis of preclinical and clinical studies. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 47(7), 1315–1330. https://doi.org/10.1038/s41386-022-01322-4
Dobson, F., Hinman, R. S., Hall, M., Terwee, C. B., Roos, E. M., & Bennell, K. L. (2012). Measurement properties of performance-based measures to assess physical function in hip and knee osteoarthritis: a systematic review. Osteoarthritis and cartilage, 20(12), 1548–1562. https://doi.org/10.1016/j.joca.2012.08.015
Martel-Pelletier, J., & Pelletier, J. P. (2010). Effects of diacerein at the molecular level in the osteoarthritis disease process. Therapeutic advances in musculoskeletal disease, 2(2), 95–104. https://doi.org/10.1177/1759720X09359104
Moldovan, F., Pelletier, J. P., Jolicoeur, F. C., Cloutier, J. M., & Martel-Pelletier, J. (2000). Diacerhein and rhein reduce the ICE-induced IL-1beta and IL-18 activation in human osteoarthritic cartilage. Osteoarthritis and cartilage, 8(3), 186–196. https://doi.org/10.1053/joca.1999.0289
Domagala, F., Martin, G., Bogdanowicz, P., Ficheux, H., & Pujol, J. P. (2006). Inhibition of interleukin-1betainduced activation of MEK/ERK pathway and DNA binding of NF-kappaB and AP-1: potential mechanism for Diacerein effects in osteoarthritis. Biorheology, 43(3,4), 577–587.
Chen, B., Zhan, H., Marszalek, J., Chung, M., Lin, X., Zhang, M., Pang, J., & Wang, C. (2016). Traditional Chinese Medications for Knee Osteoarthritis Pain: A Meta-Analysis of Randomized Controlled Trials. The American journal of Chinese medicine, 44(4), 677–703. https://doi.org/10.1142/S0192415X16500373
Zhang, Y. S., Han, J. Y., Iqbal, O., & Liang, A. H. (2018). Research Advances and Prospects on Mechanism of Sinomenin on Histamine Release and the Binding to Histamine Receptors. International journal of molecular sciences, 20(1), 70. https://doi.org/10.3390/ijms20010070
Zhang, W., Wang, S., Zhang, R., Zhang, Y., Li, X., Lin, Y., & Wei, X. (2016). Evidence of Chinese herbal medicine Duhuo Jisheng decoction for knee osteoarthritis: a systematic review of randomised clinical trials. BMJ open, 6(1), e008973. https://doi.org/10.1136/bmjopen-2015-008973
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Licensing
Ninety Nine Publication publishes articles under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This licensing allows for any use of the work, provided the original author(s) and source are credited, thereby facilitating the free exchange and use of research for the advancement of knowledge.
Detailed Licensing Terms
Attribution (BY): Users must give appropriate credit, provide a link to the license, and indicate if changes were made. Users may do so in any reasonable manner, but not in any way that suggests the licensor endorses them or their use.
No Additional Restrictions: Users may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
