EVALUATION OF SOME LIVER ENZYMES AND ALPHA-FETOPROTEIN IN WORKERS OCCUPATIONALLY EXPOSED TO E-WASTE IN NNEWI, ANAMBRA STATE NIGERIA
DOI:
https://doi.org/10.61841/x7j5n426Keywords:
Enzyme, AST, ALT, Liver, fetoprotein, e-waste, electrical materials, LFT.Abstract
Background: The advent of electricity has spurred significant technological advancements, leading to the production of numerous electrical and electronic devices. This progress, however, has resulted in a surge of largely irreparable electronic waste (e-waste) being constantly shipped to Nnewi, a metropolitan city with large-scale commercial and industrial activities. E-waste contains thousands of chemicals, many of which are toxic to humans upon exposure.
Aim Of The Study: To evaluate the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and serum levels of alpha-fetoprotein (AFP) in workers occupationally exposed to e-waste.
Methodology: The study comprised 40 e-waste workers (exposed group) and 40 healthy individuals (control group). Approximately 5 ml of venous blood was collected from each participant. The liver enzymes – ALT, AST, and ALP were evaluated colorimetrically, while AFP was assayed by Enzyme-linked Immunosorbent Assay (ELISA) method. Data obtained was statistically analyzed using SPSS windows version 25 with significance set as p<0.05 at 95% confidence interval; Independent T-test, descriptive statistics and Pearson correlation were employed where relevant. Results were presented as means ± standard deviation in contingency tables.
Result: There was no significant difference (p>0.05) in the activities of ALT, AST, ALP and serum level of AFP between the exposed subjects and the control. However, significanly negative correlation was found between age and ALT (r = -0.294; p= 0.024), while DOE also had negative correlation with ALP (r= -0.294; P= 0.024) - all among e-waste exposed group.
Conclusion: This study has shown that exposure to e-waste may not have a harmful effect on the liver function, since there was no significant difference in the liver function enzymes, and serum levels of AFP. However, age and longer duration of exposure to e-waste could be detrimental to health.
References
Abalansa S, Mahrad BEI, Icely J, .Newton A. Electronic Waste, an Environmental Problem Exported to Developing Countries: The good, the bad and the ugly. Sustainability, 2021; 13, 5302.
https://doi.org/10.3390/su13095302
Butta MKS, Omar A, Yang X. Electronic waste: A growing concern in today’s environment. Econom Res Intl., 2011; (2011), 1-8.
Igharo OG, Anetor JI, Osibanjo OO, Osadolor H B, Idomeh FA, Igiewe WO, Kalikwu OU. Liver Damage Risk Assessment Study in Workers Occupationally Exposed to E-waste in Benin City, South-South Nigeria. J Chem Health Risks, 2015; 5(3), 155–166
Ankit Saha L, Kumar V, Tiwari J, Sweta Rawat S, Singh J, Bauddh K. Electronic waste and their leachates impact on human health and environment: Global ecological threat and management. Environ Technol Innov. 2021;24(2):102049.
Maphosa V, Maphosa MF. E-Waste Management in Sub-Saharan Africa: A Systematic Literature Review. Cogent Bus Manag. 2018;7(1):1.
UNEP, 2019. Technical guidelines on transboundary movements of electrical and electronic waste and used electrical and electronic equipment, in particular regarding the distinction between waste and non-waste under the Basel Convention. (Version of 10 May 2019). United Nations Environment Programme (UNEP).
Chakraborty S, Qamruzzaman M, Zaman M, Alam M, Hossain D, et al. Metals in e-waste: Occurrence, fate, impacts and remediation technologies. Process Saf Environ Prot. 2022;162.
Lebbie ST, Moyebi DO, Asante KA, Fobil J, Brune-Drisse MN, Suk WA, et al. E-Waste in Africa: A Serious Threat to the Health of Children. Int J Environ Res Public Health. 2021;18(16):8488.
Andeobu L, Wibowo S, Grandhi S. A systematic review of E-waste generation and environmental management of Asia Pacific countries. Int J Environ Res Public Health. 2021;18(17):9051.
Andeobu L, Wibowo S, Grandhi S. An assessment of E-waste generation and environmental management of selected countries in Africa, Europe and North America: A systematic review. Sci Total Environ. 2021;792:148078.
Forti V, Baldé P, Kuehr R, Bel G, Adrian S, Drisse M, et al. Quantities, flows, and the circular economy potential The Global E-waste Monitor 2020 [Internet]. 2020. Available from: https://ewastemonitor.info/wpcontent/uploads/2020/11/GEM_2020_def_july1_low.pdf Accessed 31 March 2024.
Udechukwu C. Made in Anambra export strategy [Internet]. 2023 [cited 2024 Mar 30]. Available from:
https://anambrastate.gov.ng/wp-content/uploads/Anambra-Export-Strategy_-December-2023.pdf
Iguh NA, Ewulum BE, Origbakpor CE. Revisiting the waste management framework in Anambra State under this current dispensation. IBJ [Internet]. 2021 [cited 2024 Mar 30];2:1–12. Available from:
https://journals.ezenwaohaetorc.org/index.php/IBJ/article/viewFile/1706/1741.
Ononuju AH, Abugu AI, Obayi AN, Bosah CN, Dibiah SIC, Enemuo NK. Solid waste management in anambra state, nigeria: impediments and optimization strategies. EM International [Internet]. 2021 [cited 2024 Mar 30];40(2). Available from: http://www.envirobiotechjournals.com/article_abstract.php?aid=11536&iid=332&jid=4
Uzoukwu BA, Onamake OR. Physico chemical studies of soils along the banks of milli shallow stream in Nnewi, Anambra State of Nigeria for evidence of industrial pollution. Global Journal of Pure and Applied Sciences, 2004; 10(1),111-119.
Yan X, Li SY, Wang MH, Xu RF, Zheng J, Ren MZ. Liver and Kidney Function of E-waste Dismantling Workers and Potential Influencing Factors. Huan Jing Ke Xue. 2018 Feb 8;39(2):953-960. Chinese. doi:
a. 10.13227/j.hjkx.201708101.
Shoukat A, Nurulain, Syed Muhammad, Hussain S, Khan SA, Ahmed H, Muneer Z, et al. Chronic exposure to electronic waste poses risk to liver toxicity with molecular interaction of GSTM1, GSTT1 null variants, and GSTP1. Environmental Pollution [Internet]. 2023;334:122204. Available from:
https://www.sciencedirect.com/science/article/pii/S026974912301206X
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