THE ROLE OF INTIMA-MEDIA-THICKNESS, ANKLE-BRACHIAL-INDEX, AND INFLAMMATORY BIOCHEMICAL PARAMETERS FOR STROKE RISK PREDICTION: AN UPDATE SYSTEMATIC REVIEW

Authors

  • Azda Aulia Fajri Faculty of Medicine, Sultan Agung Islamic University, Semarang, Indonesia Author
  • Budi Hartono Faculty of Medicine, Brawijaya University, Malang, Indonesia Author
  • Deby Priscika Putri Faculty of Medicine, Diponegoro University, Semarang, Indonesia Author
  • Ririn Azhari H Bakri Sungai Penuh Regional General Hospital, Jambi, Indonesia Author
  • Bella Merisa L Faculty of Medicine, University of Jambi, Indonesia Author
  • Astrid Ananda Rimbo Medika Mother and Child Hospital, Jambi, Indonesia Author
  • Afdila Syarfina Dr. Achmad Mochtar Regional General Hospital, Bukittinggi, Indonesia Author

DOI:

https://doi.org/10.61841/4253ps11

Keywords:

Intima-media-thickness, ankle-brachial-index, inflammatory biochemical parameters, stroke risk

Abstract

Background: Stroke is a leading cause of global mortality and morbidity. The capacity to precisely estimate a person's risk of having a stroke is critical for early intervention and prevention stretegies. Researchers are exploring novel predictors beyond traditional risk factors, such as Intima-Media Thickness (IMT), Ankle-Brachial Index (ABI), and inflammatory biochemical parameters, to accurately predict stroke risk.

The aim: This study aims to determine the role of intima-media-thickness, ankle-brachial-index, and inflammatory biochemical parameters for stroke risk prediction.

Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and MetaAnalysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2014 and 2024 were taken into account. Several different online reference sources, like Pubmed, SAGEPUB, and ScienceDirect, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.

Results: In the PubMed database, the results of our search brought up 1,004 articles, whereas the results of our search on SAGEPUB brought up 651 articles, and our search on ScienceDirect brought up 4,254 articles. In the end, we compiled 12 papers, 8 of which came from PubMed, 1 of which came from SAGEPUB, and 3 of which came from ScienceDirect. We included twelve research that met the criteria.

Conclusion: In conclusion, the findings of our study strongly support that Carotid Intima-Media Thickness (CIMT) and Ankle-Brachial Index (ABI) hold significant promise as predictors of stroke risk. This can be helpful to improve stroke prevention and management strategies. However, further research is warranted to clarify the role of inflammatory biochemical parameters in the context of stroke risk prediction.

References

Murphy SJ, Werring DJ. Stroke: causes and clinical features. Vol. 48, Medicine (United Kingdom). Elsevier Ltd; 2020. p. 561–6.

Katan M, Luft A. Global Burden of Stroke. Semin Neurol. 2018 Apr 1;38(2):208–11.

Owolabi MO, Thrift AG, Mahal A, Ishida M, Martins S, Johnson WD, et al. Primary stroke prevention worldwide: translating evidence into action. Vol. 7, The Lancet Public Health. Elsevier Ltd; 2022. p. e74–85.

Kumar P, Sharma R, Misra S, Kumar A, Nath M, Nair P, et al. CIMT as a risk factor for stroke subtype: A systematic review. Vol. 50, European Journal of Clinical Investigation. Blackwell Publishing Ltd; 2020.

Bryniarski KL, Tokarek T, Bryk T, Rutka J, Gawlik I, Żabówka A, et al. Intima-media thickness and anklebrachial index are correlated with the extent of coronary artery disease measured by the SYNTAX score. Postepy w Kardiologii Interwencyjnej. 2018;14(1):52–8.

Lubrano V. Consolidated and emerging inflammatory markers in coronary artery disease. World J Exp Med. 2015;5(1):21.

Della Corte V, Todaro F, Cataldi M, Tuttolomondo A. Atherosclerosis and Its Related Laboratory Biomarkers. Vol. 24, International Journal of Molecular Sciences. Multidisciplinary Digital Publishing Institute (MDPI); 2023.

Danuaji R, Suroto S, Purwanto B, Indarto D, Muhammad F, Mirawati DK, et al. Association between carotid intima media thickness and acute ischemic stroke at an Indonesian tertiary referral hospital. J Taibah Univ Med Sci. 2023 Aug 1;18(4):771–7.

Donovan K, Herrington WG, Paré G, Pigeyre M, Haynes R, Sardell R, et al. Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases A Mendelian Randomization Study. Clinical Journal of the American Society of Nephrology. 2023;18(1):17–27.

Gronewold J, Bauer M, Lehmann N, Mahabadi AA. Coronary Artery Calcification, Intima-Media Thickness, and Ankle-Brachial Index Are Complementary Stroke Predictors. Stroke. 2014;44(SUPPL. 1).

Gronewold J, Hermann DM, Lehmann N, Kröger K, Lauterbach K, Berger K, et al. Ankle-brachial index predicts stroke in the general population in addition to classical risk factors. Atherosclerosis. 2014;233(2):545–50.

Lee KN, Chou LP, Liu CC, Chen TS, Lui EKT, Chou CH, et al. Predictive value of ankle–brachial index for long-term events of ischemic stroke in hemodialysis patients. Vascular. 2021 Feb 1;29(1):119–25.

Shi Y, Hu L, Li M, Ding C, Zhou W, Wang T, et al. The ankle–brachial index and risk of incident stroke in Chinese hypertensive population without atrial fibrillation: A cross-sectional study. J Clin Hypertens. 2021 Jan 1;23(1):114–21.

Shimoda S, Kitamura A, Imano H, Cui R, Muraki I, Yamagishi K, et al. Associations of carotid intima-media thickness and plaque heterogeneity with the risks of stroke subtypes and coronary artery disease in the japanese general population: The circulatory risk in communities study. J Am Heart Assoc. 2020 Oct 6;9(19).

Sun P, Liu L, Liu C, Zhang Y, Yang Y, Qin X, et al. Carotid Intima-Media Thickness and the Risk of First Stroke in Patients With Hypertension. Stroke. 2020 Feb 1;51(2):379–86.

Wang M, Wang S, Wang X, Wu J, Wu Y, Wang Z, et al. Carotid Intima-Media Thickness, Genetic Risk, and Ischemic Stroke: A Family-Based Study in Rural China. Public Health [Internet]. 2021;18:119. Available from: https://dx.doi.org/10.3390/ijerph18010119

Wang FM, Yang C, Ballew SH, Kalbaugh CA, Meyer ML, Tanaka H, et al. Ankle-brachial index and subsequent risk of incident and recurrent cardiovascular events in older adults: The Atherosclerosis Risk in Communities (ARIC) study. Atherosclerosis. 2021 Nov 1;336:39–47.

Yang MC, Huang YY, Hsieh SH, Sun JH, Wang CC, Lin CH. Ankle-Brachial Index Is Independently Associated With Cardiovascular Outcomes and Foot Ulcers in Asian Patients With Type 2 Diabetes Mellitus. Front Endocrinol (Lausanne). 2021 Nov 18;12.

Zhou P, Shen Y, Wang L, Cao Z, Feng W, Liu J, et al. Association between carotid intima media thickness and small dense low-density lipoprotein cholesterol in acute ischaemic stroke. Lipids Health Dis. 2020 Jul 28;19(1).

Lehmann ALCF, Alfieri DF, de Araújo MCM, Trevisani ER, Nagao MR, Pesente FS, et al. Carotid intima media thickness measurements coupled with stroke severity strongly predict short-term outcome in patients with acute ischemic stroke: a machine learning study. Metab Brain Dis. 2021 Oct 1;36(7):1747–61.

Saxena Y, Saxena V, Mittal M, Srivastava M, Raghuvanshi S. Age-wise association of carotid intima media thickness in ischemic stroke. Ann Neurosci. 2017 May 1;24(1):5–11.

Paraskevas KI, Sillesen HH, Rundek T, Mathiesen EB, Spence JD. Carotid Intima–Media Thickness Versus Carotid Plaque Burden for Predicting Cardiovascular Risk. Vol. 71, Angiology. SAGE Publications Inc.; 2020. p. 108–11.

Carpenter M, Sinclair H, Kunadian V. Carotid intima media thickness and its utility as a predictor of cardiovascular disease: A review of evidence. Vol. 24, Cardiology in Review. Lippincott Williams and Wilkins; 2016. p. 70–5.

Hong J Bin, Leonards CO, Endres M, Siegerink B, Liman TG. Ankle-Brachial Index and Recurrent Stroke Risk Meta-Analysis. Stroke. 2016 Feb 1;47(2):317–22.

Abboud H, Monteiro Tavares L, Labreuche J, Arauz A, Bryer A, Lavados PM, et al. Impact of Low AnkleBrachial Index on the Risk of Recurrent Vascular Events: Insights From the OPTIC Registry. Stroke. 2019 Apr 1;50(4):853–8.

Fan H, Hu X, Yu W, Cao H, Wang J, Li J, et al. Low ankle-brachial index and risk of stroke. Vol. 229, Atherosclerosis. 2013. p. 317–23.

Bhatt SK, Tseng AS, Firth C, Girardo M, Sykora D, Abdelmalek M, et al. Abnormal vascular physiology in the lower extremities as a risk factor for ischemic stroke and mortality. Journal of Osteopathic Medicine. 2021 May 1;121(5):463–70.

Downloads

Published

2024-03-26

How to Cite

Fajri, A. A., Hartono, B., Putri, D. P., Azhari, R., L, B. M., Ananda, A., & Syarfina, A. (2024). THE ROLE OF INTIMA-MEDIA-THICKNESS, ANKLE-BRACHIAL-INDEX, AND INFLAMMATORY BIOCHEMICAL PARAMETERS FOR STROKE RISK PREDICTION: AN UPDATE SYSTEMATIC REVIEW. Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 10(3), 307-315. https://doi.org/10.61841/4253ps11

Similar Articles

11-20 of 231

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)

1 2 > >>