ASSOCIATION OF THYROID FUNCTION AND POST TRAUMATIC STRESS DISORDER: A SYSTEMATIC REVIEW

Authors

  • Pretika Prameswari Faculty of Medicine, Trisakti University, Jakarta, Indonesia Author
  • Ririn Azhari H Bakri Sungai Penuh General Hospital, Jambi, Indonesia Author

DOI:

https://doi.org/10.61841/pp7qm289

Keywords:

Posttraumatic stress disorder, PTSD, thyroid

Abstract

Background: Numerous studies conducted over the last few decades have shown a negative correlation between posttraumatic stress disorder PTSD and physical health and wellbeing. Thyroid dysfunction may be related to a variety of mental disorders, including PTSD. However, it is still debatable.

 The aim: This study aims to investigate association between thyroid function and post-traumatic stress disorder.

Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and MetaAnalysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2013 and 2023 were taken into account. Several different online reference sources, like Pubmed and ScienceDirect, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.

Results: In the PubMed database, the results of our search brought up 42 articles, whereas the results of our search on ScienceDirect brought up 163 articles. The results of the search conducted by title screening yielded a total 15 articles for PubMed and 10 articles for ScienceDirect. We compiled a total of 14 papers, 11 of which came from PubMed and 3 of which came from ScienceDirect. We excluded 3 review articles, 3 duplicate articles, 1 animal study, and 2 articles having ineligible outcomes data. In the end, we included five research that met the criteria.

Conclusion: PTSD may alter thyroid function but there is scanty evidence regarding their relationship.

References

Persike DS, Al-Kass SY. Challenges of post-traumatic stress disorder (PTSD) in Iraq: Biochemical network and methodologies. A brief review. Vol. 41, Hormone Molecular Biology and Clinical Investigation. De Gruyter Open Ltd; 2020.

Martin A, Naunton M, Kosari S, Peterson G, Thomas J, Christenson JK. Treatment guidelines for PTSD: A systematic review. Vol. 10, Journal of Clinical Medicine. MDPI; 2021.

Nichter B, Norman S, Haller M, Pietrzak RH. Physical health burden of PTSD, depression, and their comorbidity in the U.S. veteran population: Morbidity, functioning, and disability. J Psychosom Res. 2019 Sep 1;124.

Raise-Abdullahi P, Meamar M, Vafaei AA, Alizadeh M, Dadkhah M, Shafia S, et al. Hypothalamus and Post-Traumatic Stress Disorder: A Review. Vol. 13, Brain Sciences. Multidisciplinary Digital Publishing Institute (MDPI); 2023.

Christiansen DM, Berke ET. Gender- and Sex-Based Contributors to Sex Differences in PTSD. Vol. 22, Current Psychiatry Reports. Springer; 2020.

Atwoli L, Stein DJ, Koenen KC, McLaughlin KA. Epidemiology of posttraumatic stress disorder: Prevalence, correlates and consequences. Vol. 28, Current Opinion in Psychiatry. Lippincott Williams and Wilkins; 2015. p. 307–11.

Demartini B, Ranieri R, Masu A, Selle V, Scarone S, Gambini O. Depressive symptoms and major depressive disorder in patients affected by subclinical hypothyroidism: A cross-sectional study. Journal of Nervous and Mental Disease. 2014;202(8):603–7.

Moini J, Pereira K, Samsam M. Thyroid dysfunction and mental disorders. In: Epidemiology of Thyroid Disorders. Elsevier; 2020. p. 191–206.

Feklicheva I, Boks MP, de Kloet ER, Chipeeva N, Maslennikova E, Pashkov A, et al. Biomarkers in PTSD-susceptible and resistant veterans with war experience of more than ten years ago: FOCUS ON cortisol, thyroid hormones, testosterone and GABA. J Psychiatr Res. 2022 Apr 1;148:258–63.

Jung SJ, Kang JH, Roberts AL, Nishimi K, Chen Q, Sumner JA, et al. Posttraumatic stress disorder and incidence of thyroid dysfunction in women. Psychol Med. 2019 Nov 1;49(15):2551–60.

Musheyev Y, Levada M, Ftiha F, Garrick I, Ahasan H, Jiang M. Panhypopituitarism Presents As Amenorrhea Secondary to Post Traumatic Stress Disorder in a 33-Year-Old Patient: A Case Report. Cureus. 2022 Mar 3;

O’Donovan A, Cohen BE, Seal KH, Bertenthal D, Margaretten M, Nishimi K, et al. Elevated risk for autoimmune disorders in iraq and afghanistan veterans with posttraumatic stress disorder. Biol Psychiatry. 2015;77(4):365–74.

Sinai C, Hirvikoski T, Nordström AL, Nordström P, Nilsonne Å, Wilczek A, et al. Hypothalamic pituitary thyroid axis and exposure to interpersonal violence in childhood among women with borderline personality disorder. Eur J Psychotraumatol. 2014;5(SUPPL).

Trifu S, Tudor A, Radulescu I. Aggressive behavior in psychiatric patients in relation to hormonal imbalance (Review). Exp Ther Med. 2020 Jul 7;

Radhakrishnan R, Calvin S, Singh JK, Thomas B, Srinivasan K. Thyroid dysfunction in major psychiatric disorders in a hospital based sample.

Kamble MT, Nandedkar PD, Dharme P V., Lokhande Suryabhan L, Bhosale PG. Thyroid function and mental disorders: An insight into the complex interaction. Journal of Clinical and Diagnostic Research. 2013 Jan 1;7(1):11–4.

Bunevicius R. Thyroid disorders in mental patients. Vol. 22, Current Opinion in Psychiatry. 2009. p. 391–5.

Downloads

Published

2023-12-13

How to Cite

Prameswari, P., & Azhari, R. (2023). ASSOCIATION OF THYROID FUNCTION AND POST TRAUMATIC STRESS DISORDER: A SYSTEMATIC REVIEW. Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 9(12), 62-68. https://doi.org/10.61841/pp7qm289

Similar Articles

1-10 of 71

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)

1 2 > >>