HIDRADENITIS SUPPURATIVA AND DIABETES MELLITUS: A SYSTEMATIC REVIEW

Authors

  • Yeyen Jani Sari Dabukke Faculty of Medicine, University of Methodist, Indonesia Author

Keywords:

Alopecia areata, covid-19, hair loss

Abstract

Objective: Hidradenitis suppurativa (HS), also known as acne inversus is a persistent inflammatory skin disease. This condition causes lesions such as deep-seated nodules and abscesses, draining tracts, and fibrotic scars. Preliminary data indicates a possible biological connection between diabetes mellitus (DM) and HS. This study aimed to review the correlation between hidradenitis suppurative and diabetes mellitus systematically.

Materials and methods: A systematic search strategy was conducted across several electronic reference databases (PubMed, Cochrane Library, ProQuest) and included articles published between 2019–2023. Duplicate publications, review articles, and incomplete articles were excluded.

Results: Database search yielded 214 articles, which were systematically eliminated, leaving 5 relevant articles. Analyzed articles showed the association between diabetes mellitus and hidradenitis suppurativa.

Conclusion: Studies support a significant relationship between HS and DM. Although the prevalence was variative, the association between the two conditions was significant.

References

Seyed Jafari SM, Hunger RE, Schlapbach C. Hidradenitis Suppurativa: Current Understanding of Pathogenic Mechanisms and Suggestion for Treatment Algorithm. Front Med. 2020;7(March):18–20.

Ingram JR. The epidemiology of hidradenitis suppurativa. Br J Dermatol. 2020;183(6):990–8.

Chandran NS, Lee JH, Kurokawa I. Hidradenitis suppurativa in South-East Asia and East Asia. Exp Dermatol. 2021;30(S1):23–6.

Napolitano M, Megna M, Timoshchuk EA, Patruno C, Balato N, Fabbrocini G, et al. Hidradenitis suppurativa: From pathogenesis to diagnosis and treatment. Clin Cosmet Investig Dermatol. 2017;10:105–15.

Kohorst JJ, Kimball AB, Davis MDP. Systemic associations of hidradenitis suppurativa. J Am Acad Dermatol [Internet] 2015;73(5):S27–35. Available from: http://dx.doi.org/10.1016/j.jaad.2015.07.055

Frew JW. Hidradenitis suppurativa and diabetes: big data bias masks a true association. Clin Exp Dermatol. 2019;44(4):e151–2.

Jørgensen AHR, Yao Y, Ghazanfar MN, Ring HC, Thomsen SF. Burden, predictors and temporal relationships of comorbidities in patients with hidradenitis suppurativa: a hospital-based cohort study. J Eur Acad Dermatology Venereol. 2020;34(3):565–73.

Yüksel M, Basım P. Demographic and Clinical Features of Hidradenitis Suppurativa in Turkey. J Cutan Med Surg. 2020;24(1):55–9.

Reddy S, Strunk A, Garg A. Comparative Overall Comorbidity Burden among Patients with Hidradenitis Suppurativa. JAMA Dermatology. 2019;155(7):797–802.

Kluger N, Nuutinen P, Lybeck E, Ruohoalho T, Salava A. Type 2 diabetes mellitus in a cohort of Finnish patients with hidradenitis suppurativa. J Eur Acad Dermatology Venereol. 2020;34(2):e98–100.

Garg A, Birabaharan M, Strunk A. Prevalence of type 2 diabetes mellitus among patients with hidradenitis suppurativa in the United States. J Am Acad Dermatol [Internet] 2018;79(1):71–6. Available from: https://doi.org/ 10.1016/j.jaad.2018.01.014

Brandão LAC, Tricarico PM, Gratton R, Agrelli A, Zupin L, Abou-Saleh H, et al. Multiomics integration in skin diseases with alterations in notch signaling pathway: PlatOMICs phase 1 deployment. Int J Mol Sci. 2021;22(4):1– 10.

Nguyen T V., Damiani G, Orenstein LAV, Hamzavi I, Jemec GB. Hidradenitis suppurativa: an update on epidemiology, phenotypes, diagnosis, pathogenesis, comorbidities and quality of life. J Eur Acad Dermatology Venereol. 2021;35(1):50–61.

Bettoli V, Naldi L, Cazzaniga S, Zauli S, Atzori L, Borghi A, et al. Overweight, diabetes and disease duration influence clinical severity in hidradenitis suppurativa-acne inversa: Evidence from the national Italian registry. Br J Dermatol. 2016;174(1):195–7.

Miller IM, McAndrew RJ, Hamzavi I. Prevalence, Risk Factors, and Comorbidities of Hidradenitis Suppurativa. Dermatol Clin [Internet] 2016;34(1):7–16. Available from: http://dx.doi.org/10.1016/j.det.2015.08.002

Jiang SW, Whitley MJ, Mariottoni P, Jaleel T, MacLeod AS. Hidradenitis Suppurativa: Host-Microbe and Immune Pathogenesis Underlie Important Future Directions. JID Innov [Internet] 2021;1(1):100001. Available from: https://doi.org/10.1016/j.xjidi.2021.100001

Garg A, Malviya N, Strunk A, Wright S, Alavi A, Alhusayen R, et al. Comorbidity screening in hidradenitis suppurativa: Evidence-based recommendations from the US and Canadian Hidradenitis Suppurativa Foundations. J Am Acad Dermatol [Internet] 2022;86(5):1092–101. Available from: https://doi.org/10.1016/j.jaad.2021.01.059

Phan K, Charlton O, Smith SD. Hidradenitis suppurativa and diabetes mellitus: updated systematic review and adjusted meta-analysis. Clin Exp Dermatol. 2019;44(4):e126–32.

González-López MA, Ocejo-Viñals JG, Mata C, Vilanova I, Guiral S, Portilla V, et al. Association of retinol binding protein4 (RBP4) and ghrelin plasma levels with insulin resistance and disease severity in non-diabetic patients with hidradenitis suppurativa. Exp Dermatol. 2020;29(9):828–32.

González-López MA, Vilanova I, Ocejo-Viñals G, Arlegui R, Navarro I, Guiral S, et al. Circulating levels of adiponectin, leptin, resistin and visfatin in non-diabetics patients with hidradenitis suppurativa. Arch Dermatol Res [Internet] 2020;312(8):595–600. Available from: https://doi.org/10.1007/s00403-019-02018-4

Bui TL, Silva-Hirschberg C, Torres J, Armstrong AW. Hidradenitis suppurativa and diabetes mellitus: A systematic review and meta-analysis. J Am Acad Dermatol [Internet] 2018;78(2):395–402. Available from: https://doi.org/ 10.1016/j.jaad.2017.08.042

Karagiannidis I, Nikolakis G, Zouboulis CC. Endocrinologic Aspects of Hidradenitis Suppurativa. Dermatol Clin. 2016;34(1):45–9.

Edigin E, Kaul S, Eseaton PO. Analysis of hidradenitis suppurativa hospitalizations: A report from the National Inpatient Sample database. J Am Acad Dermatol. 2021;85(5):1357–60.

Ahmad S, Riddle AO, Sayed CJ. Outcomes of Routine Diabetes Screening for Patients with Hidradenitis Suppurativa. J Invest Dermatol. 2021;141(4):927–30.

Ingram JR, Jenkins-Jones S, Knipe DW, Morgan CLI, Cannings-John R, Piguet V. Population-based Clinical Practice Research Datalink study using algorithm modelling to identify the true burden of hidradenitis suppurativa. Br J Dermatol. 2018;178(4):917–24.

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Published

2023-03-10

How to Cite

Dabukke, Y. J. S. (2023). HIDRADENITIS SUPPURATIVA AND DIABETES MELLITUS: A SYSTEMATIC REVIEW . Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 9(3), 42-46. https://jarmhs.com/MHS/index.php/mhs/article/view/146

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