EFFECT OF FASTING AND POSTPRANDIAL BLOOD SAMPLES IN RESULTS ON THYROID FUNCTION TEST AMONG EUTHYROID PEOPLE AND PATIENTS WITH THYROID PROBLEM: A SYSTEMATIC REVIEW
Keywords:
Circadian rhythm, Blood samples, Euthyroid, ThyroidAbstract
The normal 24-hour rhythm of circulating TSH has a maximum between the hours of 11 p.m. and 5 a.m., and a minimum between the hours of 5 p.m. and 8 p.m. Secretory pulses occur approximately every two to three hours, and they are interspersed with periods of tonic, non-pulsatile TSH production. Although TSH secretion is pulsatile, relatively minor circulatory fluctuations are produced as a result due to the low amplitude of the pulses and the prolonged half-life of TSH. In most cases, the TSH levels taken first thing in the morning during fasting situations are found to be much greater than those obtained later in the same day. When compared to the postprandial blood samples, the TSH result value for the usage of blood samples taken while the patient was fasting would be much greater. As a result, this could be useful in the introduction of a new guideline to standardize the blood sample status for the TSH test screening and diagnosis. The foodinduced increase in circulating somatostatin and consequent suppression of TSH levels is one idea that may help to explain the acute postprandial decline in serum TSH levels. Varying increases in plasma somatostatin-14 and somatostatin-28, the two primary bioactive forms, have been recorded in normal volunteers after liquid and solid test meals, with the peak occurring 90–120 minutes after ingestion, likely reflecting somatostatin release from the stomach.
References
Koulouri O, Moran C, Halsall D, Chatterjee K, Gurnell M. Pitfalls in the measurement and interpretation of thyroid function tests. Best Pract Res Clin Endocrinol Metab. 2013;27(6):745–62.
Dayan CM. Interpretation of thyroid function tests. Lancet. 2001;357(9256):619–24.
Fauci AS, Jameson JL, Kasper D, et al. Harrison’s Principles of Internal Medicine 19th Edition. New York: McGrawHill Education; 2018.
Sherwood L. Introduction to Human Physiology. 9th ed. US: Cengage Learning; 2015.
Mariotti S, Beck-Peccoz P. Physiology of the hypothalamic-pituitary-thyroid axis. Endotext [Internet] 2021; [6] Carvalho GA de, Perez CLS, Ward LS. The clinical use of thyroid function tests. Arq Bras Endocrinol Metabol. 2013;57:193–204.
Brabant G, Prank K, Ranft U, Schuermeyer T, Wagner TOF, Hauser H, et al. Physiological regulation of circadian and pulsatile thyrotropin secretion in normal man and woman. J Clin Endocrinol Metab. 1990;70(2):403–9.
Persani L, Terzolo M, Asteria C, Orlandi F, Angeli A, Beck-Peccoz P. Circadian variations of thyrotropin bioactivity in normal subjects and patients with primary hypothyroidism. J Clin Endocrinol Metab. 1995;80(9):2722–8.
Nair R, Mahadevan S, Muralidharan RS, Madhavan S. Does fasting or postprandial state affect thyroid function testing? Indian J Endocrinol Metab. 2014 Sep;18(5):705–7.
Mahadevan S, Sadacharan D, Kannan S, Suryanarayanan A. Does time of sampling or food intake alter thyroid function test? Indian J Endocrinol Metab. 2017;21(3):369.
Pradeep TVS, Varma SH, Tirupati S, Sarathi V, Kumar KD. Postprandial decline in thyroid-stimulating hormone is significant but not its correlation with postprandial change in plasma glucose. Thyroid Res Pract. 2018;15(3):113–
Price SA, Lorraine MW. Patofisiologi Konsep Klinis Proses-Proses Penyakit. Jakarta: EGC; 2016.
Ganong F; William. Buku Ajar Fisiologi Kedokteran. 22nd ed. Jakarta: EGC; 2013.
Setiati S, Alwi I, Sudoyo AW, Sumadibrata M, Setiyohadi B, Syam AF. Buku Ajar Ilmu Penyakit Dalam. 6th ed. Jakarta: Interna Publishing; 2014.
AIN KB, PUCINO F, SHIVER TM, BANKS SM. Thyroid hormone levels affected by time of blood sampling in thyroxine-treated patients. Thyroid. 1993;3(2):81–5.
De Groot L; Abalovich M; Alexander EK; et al. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2012;97(8):2543–65.
Bandophadhyay D, Goel P, Baruah H, Sharma D. Fasting or random: Which venous sample is better for thyroid function testing. JARBS. 2012;4:275–8.
Udiong CEJ, Udoh AE, Etukudoh ME. Evaluation of thyroid function in diabetes mellitus in Calabar, Nigeria. Indian J Clin Biochem. 2007;22:74–8.
Hildebrand P, Ensinck JW, Buettiker J, Drewe J, Burckhardt B, Gyr K, et al. Circulating somatostatin‐28 is not a physiologic regulator of gastric acid production in man. Eur J Clin Invest. 1994;24(1):50–6.
Carvalho DP, Ferreira AC, Coelho SM, Moraes JM, Camacho MA, Rosenthal D. Thyroid peroxidase activity is inhibited by amino acids. Brazilian J Med Biol Res = Rev Bras Pesqui medicas e Biol. 2000 Mar;33(3):355–61.
Pałkowska-Goździk E, Lachowicz K, Rosołowska-Huszcz D. Effects of dietary protein on thyroid axis activity. Nutrients. 2017;10(1):5.
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