COMPARISON BETWEEN NEBULISATION OF MGSO4 20 MG/KGBW WITH KETAMINE 0.5 MG/KGBW ON THE INCIDENT OF POST-OPERATIVE SORE THROAT DUE TO ENDOTRACHEAL INTUBATION IN PATIENTS UNDERGOING GENERAL ANESTHESIA IN DR. HASAN SADIKIN HOSPITALS BANDUNG

Authors

  • Reza Widianto Sudjud Departement of Anaesthesiology and Intensive Therapy, Faculty of Medicine, Padjadjaran University / Hasan Sadikin Centre General Hospital, Bandung, Indonesia Author
  • Muchammad Erias Erlangga Departement of Anaesthesiology and Intensive Therapy, Faculty of Medicine, Padjadjaran University / Hasan Sadikin Centre General Hospital, Bandung, Indonesia Author
  • Diki Akbar Departement of Anaesthesiology and Intensive Therapy, Faculty of Medicine, Padjadjaran University / Hasan Sadikin Centre General Hospital, Bandung, Indonesia Author

DOI:

https://doi.org/10.61841/7hyssr73

Keywords:

General anesthesia, Endotracheal intubation, Ketamine, MgSO4, POST nebulization.

Abstract

Post Operative Sore Throat (POST) is a Symptoms often experienced by patients after surgery under general anesthesia and endotracheal intubation. The incidence of POST is between 21-71.8%. POST causes discomfort to patients which can prolong hospital stay. In this study, a comparison was made between MgSO4 nebulization 20 mg/ KgBW and ketamine nebulization 0.5 mg/ KgBW on the incidence of POST after general anesthesia at RSUP Dr. Hasan Sadikin Bandung . This study used a double blind randomized controlled trial design. 72 elective surgery patients were randomly divided into 2 groups. Group M was given MgSO4 nebulization while group K was given ketamine nebulization. Nebulization was performed 15 minutes before induction of general anesthesia. POST monitoring was performed at 1, 4 and 24 hours after extubation using POST scoring. In this study, it was found that the incidence of POST in group M, namely the 1st hour of 13.5%, the 4th hour of 10.8% and the 24th hour of 0% was lower than that in group K, namely the 1st hour of 28.5%, the 4th hour of 32.5% and the 24th hour of 0% . Statistical test results p=0.033 showed a significant difference in group M better than group K at the 4th hour in reducing the incidence of POST. MgSO4 and ketamine have antinociceptive and anti-inflammatory effects with the mechanism of action of blocking NMDA receptors that inhibit calcium influx that avoids central sensitization. MgSO4 also has a muscle relaxing effect and reduces airway mucus secretion, thus reducing the risk of trauma during endotracheal intubation. The conclusion of this study is that MgSO4 nebulization shows a lower incidence of POST than ketamine nebulization.

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Published

2024-05-13

How to Cite

Sudjud, R. W., Erlangga, M. E., & Akbar, D. (2024). COMPARISON BETWEEN NEBULISATION OF MGSO4 20 MG/KGBW WITH KETAMINE 0.5 MG/KGBW ON THE INCIDENT OF POST-OPERATIVE SORE THROAT DUE TO ENDOTRACHEAL INTUBATION IN PATIENTS UNDERGOING GENERAL ANESTHESIA IN DR. HASAN SADIKIN HOSPITALS BANDUNG. Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 10(5), 77-84. https://doi.org/10.61841/7hyssr73

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