THE LABORATORY PERSPECTIVE OF LEUKOCYTE DIFFERENTIAL, LYMPHOCYTE COUNT AND CELL POPULATION DATA IN EVALUATION OF SARS COV2: A COMPREHENSIVE SYSTEMATIC REVIEW

Authors

  • Anissa Paranoan Stella Maris General Hospital, Makassar, Indonesia Author
  • Anelsa Paranoan Warmare Regional General Hospital, West Papua, Indonesia Author

DOI:

https://doi.org/10.61841/9g8wng98

Keywords:

COVID-19, leukocyte, lymphocyte, neutrophils

Abstract

Background: The pathology of COVID-19 involves a dysregulation of the adaptive immune system, with hematological abnormalities being frequently reported in affected patients since the onset of the pandemic. Specifically, leukocyte differentials in SARS-CoV-2 infected individuals often exhibit neutrophilia, lymphopenia, and morphology alterations. This study aims to serve a comprehensive systematic review to examine the role of leukocyte differential, lymphocyte count, and CPD parameters to evaluate SARS-COV2 in literatures of the last 10 years. 

Methods: The review adhered to PRISMA 2020 standards and analyzed full-text English literature from 2014 to 2024. It excluded editorials, review papers from the same journal, and submissions lacking a DOI. Literature sources included PubMed, SagePub, SpringerLink, and Google Scholar. 

Result: A total of 937 articles were retrieved from online databases (PubMed, SagePub, SpringerLink and Google Scholar). After three rounds of screening, five articles directly relevant to the systematic review were selected for full-text reading and analysis.

Conclusion: The comprehensive assessment of leukocyte count, lymphocyte count, and cell population data provides invaluable insights into the immune dysregulation and disease severity in COVID-19 infection. Understanding the intricate interplay between these hematological parameters can guide clinicians in early detection, risk stratification, and tailored therapeutic interventions for patients battling COVID-19.

References

Silva EH, Lekamwasam S. Confirmatory and supportive laboratory investigations in SARS-CoV-2 infection; a systematic review. J Prev Epidemiol. 2020 Jul 6;5(1):e03–e03.

Elshazli RM, Toraih EA, Elgaml A, El-Mowafy M, El-Mesery M, Amin MN, et al. Diagnostic and prognostic value of hematological and immunological markers in COVID-19 infection: A meta-analysis of 6320 patients. PLOS ONE. 2020 Aug 21;15(8):e0238160.

Wang J, Jiang M, Chen X, Montaner LJ. Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts. Journal of Leukocyte Biology. 2020 Jul 1;108(1):17–41.

Urrechaga E, Ponga C, Fernández M, España PP, Haider RZ, Aguirre U. Diagnostic potential of leukocyte differential and cell population data in prediction of COVID-19 among related viral and bacterial infections at Emergency Department. Clinical Chemistry and Laboratory Medicine (CCLM). 2022 Apr 1;60(5):e104–7.

Patel KA, Patel B, Parmar RA, Sharma BS, Thacker M, Patel N. A study of hematological parameters in patients with COVID-19 infection at a tertiary care centre. J Pathol Nep. 2021 Mar 20;11(1):1852–8.

Balzanelli MG, Distratis P, Dipalma G, Vimercati L, Catucci O, Amatulli F, et al. Immunity Profiling of COVID-19 Infection, Dynamic Variations of Lymphocyte Subsets, a Comparative Analysis on Four Different Groups. Microorganisms. 2021 Oct;9(10):2036.

Zhang D, Guo R, Lei L, Liu H, Wang Y, Wang Y, et al. Frontline Science: COVID-19 infection induces readily detectable morphologic and inflammation-related phenotypic changes in peripheral blood monocytes. Journal of Leukocyte Biology. 2021 Jan 1;109(1):13–22.

Fumagalli RM, Chiarelli M, Cazzaniga M, Bonato C, D’Angelo L, D’Oro LC, et al. Blood cell differential count discretisation modelling to predict survival in adults reporting to the emergency room: a retrospective cohort study. BMJ Open. 2023 Nov 1;13(11):e071937.

Spijkerman R, Bongers SH, Bindels BJJ, Tinnevelt GH, Giustarini G, Jorritsma NKN, et al. Flow cytometric evaluation of the neutrophil compartment in COVID-19 at hospital presentation: A normal response to an abnormal situation. Journal of Leukocyte Biology. 2021 Jan 1;109(1):99–114.

Harte JV, Mykytiv V. A panhaemocytometric approach to COVID-19: a retrospective study on the importance of monocyte and neutrophil population data on Sysmex XN-series analysers. Clinical Chemistry and Laboratory Medicine (CCLM). 2021 Apr 1;59(5):e169–72.

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Published

2024-04-19

How to Cite

Paranoan, A., & Paranoan , A. (2024). THE LABORATORY PERSPECTIVE OF LEUKOCYTE DIFFERENTIAL, LYMPHOCYTE COUNT AND CELL POPULATION DATA IN EVALUATION OF SARS COV2: A COMPREHENSIVE SYSTEMATIC REVIEW . Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 10(4), 73-80. https://doi.org/10.61841/9g8wng98

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