EFFECTS OF VITAMIN D IN NEONATES AND YOUNG INFANTS: AN UPDATED SYSTEMATIC REVIEW

Authors

  • Grace Erdiana Faculty of Medicine, Tarumanagara University, Special Region of Jakarta, Indonesia Author
  • Glenardi Faculty of Medicine, Atma Jaya Indonesian Catholic University, Special Region of Jakarta, Indonesia Author

DOI:

https://doi.org/10.61841/cb5s0945

Keywords:

Vitamin D, neonates, infants

Abstract

Background: Vitamin D is a fat-soluble vitamin essential for calcium metabolism, maintaining calcium homeostasis, and supporting skeletal mineralization. Low maternal levels of vitamin D during pregnancy are linked to various adverse neonatal outcomes. This study aims to systematically review the effects of Vitamin D in neonates and infants in literatures of the last 5 years.

Methods: The systematic review followed PRISMA 2020 standards and examined full-text English literature published between 2019 and 2024. This review excluded editorials, review papers from the same journal, and submissions without a DOI. Literature was sourced from online platforms such as PubMed, SagePub, SpringerLink, and Google Scholar.

Result: A total of 2,866 articles were retrieved from online databases (PubMed, SagePub, SpringerLink and Google Scholar). After three rounds of screening, four articles directly relevant to the systematic review were selected for fulltext reading and analysis.

Conclusion: Vitamin D is essential for skeletal, immune, and neurodevelopmental health in children. Maternal supplementation during pregnancy is crucial for ensuring adequate levels in infants and neonates, along with promoting sunlight exposure and dietary intake, particularly in regions with high rates of maternal vitamin D deficiency.

References

Behera CK, Sahoo JP, Patra SD, Jena PK. Is Lower Vitamin D Level Associated with Increased Risk of Neonatal Sepsis? A Prospective Cohort Study. Indian J Pediatr [Internet]. 2020 Jun 1 ;87(6):427–32. Available from: https://doi.org/10.1007/s12098-020-03188-0

Mansur JL, Oliveri B, Giacoia E, Fusaro D, Costanzo PR. Vitamin D: Before, during and after Pregnancy: Effect on Neonates and Children. Nutrients [Internet]. 2022 Jan ;14(9):1900. Available from: https://www.mdpi.com/2072-6643/14/9/1900

Al-Beltagi M, Rowiesha M, Elmashad A, Elrifaey SM, Elhorany H, Koura HG. Vitamin D status in preterm neonates and the effects of its supplementation on respiratory distress syndrome. Pediatric Pulmonology [Internet]. 2020 ;55(1):108–15. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24552

Karras SN, Koufakis T, Antonopoulou V, Goulis DG, Annweiler C, Pilz S, et al. Characterizing neonatal vitamin D deficiency in the modern era: A maternal-neonatal birth cohort from Southern Europe. The Journal of Steroid Biochemistry and Molecular Biology [Internet]. 2020 Apr 1 ;198:105555. Available from: https://www.sciencedirect.com/science/article/pii/S0960076019304741

Aly H, Mohsen L, Bhattacharjee I, Malash A, Atyia A, Elanwary S, et al. Vitamin D Supplementation and T Cell Regulation in Preterm Infants: A Randomized Controlled Trial. J Pediatr Gastroenterol Nutr. 2019 Nov;69(5):607–10.

Rodgers MD, Mead MJ, McWhorter CA, Ebeling MD, Shary JR, Newton DA, et al. Vitamin D and Child Neurodevelopment-A Post Hoc Analysis. Nutrients. 2023 Oct 3;15(19):4250.

Chacham S, Rajput S, Gurnurkar S, Mirza A, Saxena V, Dakshinamurthy S, et al. Prevalence of Vitamin D Deficiency Among Infants in Northern India: A Hospital Based Prospective Study. Cureus [Internet]. 2020 Nov 5 ; Available from: https://www.cureus.com/articles/43394-prevalence-of-vitamin-d-deficiency-among-infants-in-northernindia-a-hospital-based-prospective-study

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Published

2024-03-19

How to Cite

Erdiana, G., & Glenardi. (2024). EFFECTS OF VITAMIN D IN NEONATES AND YOUNG INFANTS: AN UPDATED SYSTEMATIC REVIEW . Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 10(3), 196-202. https://doi.org/10.61841/cb5s0945

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