OBESITY AND ENDOMETRIAL HYPERPLASIA AND CANCER IN PREMENOPAUSAL WOMEN: A SYSTEMATIC REVIEW

Authors

  • Feisal Hilman Faculty of Medicine, Indonesian Islamic University, Indonesia Author
  • M Alvian Subhakti Prambanan General Hospital, Indonesia Author
  • Rafik Prabowo Rokan Hulu General Hospital, Indonesia Author

DOI:

https://doi.org/10.61841/fqank132

Keywords:

Endometrial hyperplasia, endometrial cancer, obesity, premenopausal.

Abstract

Background: Endometrial cancer (EC) represents the most common malignancy of the female reproductive tract. The precursor lesion for endometrioid adenocarcinoma of the endometrium, which comprises the majority of ECs, is endometrial hyperplasia (EH). EH is a noninvasive, abnormal proliferation of the endometrial lining of the uterus and associated with a significant risk of concurrent EC or progression to EC. The leading symptoms of EH are bleeding disorders in premenopausal women and vaginal bleeding in postmenopausal women. The most important risk factor is chronic exposure to unopposed estrogen.

The aim: This study aims to show obesity and endometrial hyperplasia and cancer in premenopausal women.

Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and MetaAnalysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2013 and 2023 were taken into account. Several different online reference sources, like Pubmed and SagePub, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.

Result: In the PubMed database, the results of our search brought up 81 articles, whereas the results of our search on SagePub brought up 112 articles. The results of the search conducted for the last year of 2013 yielded a total  29 articles for PubMed and 78 articles for SagePub. The result from title screening, a total 5 articles for PubMed and 13 articles for SagePub. In the end, we compiled a total of 8 papers. We included five research that met the criteria.

Conclusion: The nomogram of EH/EC is significantly associated with risk factors, namely BMI, PCOS, anemia, infertility, menostaxis, AUB type, and endometrial thickness. The nomogram model can be used to predict the EH/EC risk and rapidly screen risk factors in a women population with high risk.

References

Kuai D, Tang Q, Tian W, Zhang H. Rapid identification of endometrial hyperplasia and endometrial endometrioid cancer in young women. Discov Oncol [Internet]. 2023;14(1). Available from: https://doi.org/10.1007/s12672-023-00736-w

Onstad MA, Schmandt RE, Lu KH. Addressing the role of obesity in endometrial cancer risk, prevention, and treatment. J Clin Oncol. 2016;34(35):4225–30.

Chu CS. Opportunity for Intervention. 2018;69(7):990–5.

Kiesel L, Eichbaum C, Baumeier A, Eichbaum M. Obesity epidemic—the underestimated risk of endometrial cancer. Cancers (Basel). 2020;12(12):1–11.

Jia M. 乳鼠心肌提取 HHS Public Access. Physiol Behav. 2017;176(3):139–48.

Beavis AL, Najjar O, Cheskin LJ, Mangal R, Rositch AF, Langham G, et al. Prevalence of endometrial cancer symptoms among overweight and obese women presenting to a multidisciplinary weight management center.

Gynecol Oncol Reports [Internet]. 2020;34(June):100643. Available from: https://doi.org/10.1016/j.gore.2020.100643

Giannella L, Cerami LB, Setti T, Bergamini E, Boselli F. Prediction of Endometrial Hyperplasia and Cancer among Premenopausal Women with Abnormal Uterine Bleeding. Biomed Res Int. 2019;2019.

Abdol Manap N, Ng BK, Phon SE, Abdul Karim AK, Lim PS, Fadhil M. Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome. Int J Environ Res Public Health. 2022;19(15).

Zhao J, Hu Y, Zhao Y, Chen D, Fang T, Ding M. Risk factors of endometrial cancer in patients with endometrial hyperplasia: implication for clinical treatments. BMC Womens Health [Internet]. 2021;21(1):1–6. Available from: https://doi.org/10.1186/s12905-021-01452-9

Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, et al. Endometrial hyperplasia as a risk factor of endometrial cancer. Arch Gynecol Obstet [Internet]. 2022;306(2):407–21. Available from: https://doi.org/10.1007/s00404-021-06380-5

Grubman J, Mora V, Nguyen M, Ladwig N, Chen L may, Jacoby V. Impact of abnormal uterine bleeding care

in premenopausal patients prior to endometrial malignancy diagnosis. Gynecol Oncol Reports [Internet].

;50(October):101292. Available from: https://doi.org/10.1016/j.gore.2023.101292

MacKintosh ML, Derbyshire AE, McVey RJ, Bolton J, Nickkho-Amiry M, Higgins CL, et al. The impact of obesity and bariatric surgery on circulating and tissue biomarkers of endometrial cancer risk. Int J Cancer. 2019;144(3):641–50.

Papatla K, Huang M, Slomovitz B. The obese endometrial cancer patient: How do we effectively improve morbidity and mortality in this patient population? Ann Oncol [Internet]. 2016;27(11):1988–94. Available from: https://doi.org/10.1093/annonc/mdw310

Downloads

Published

2023-12-28

How to Cite

Hilman, F., Subhakti, M. A., & Prabowo, R. (2023). OBESITY AND ENDOMETRIAL HYPERPLASIA AND CANCER IN PREMENOPAUSAL WOMEN: A SYSTEMATIC REVIEW. Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 9(12), 199-205. https://doi.org/10.61841/fqank132

Similar Articles

31-40 of 76

You may also start an advanced similarity search for this article.