PRIMARY OUTCOME MEASURES IN PEDIATRIC SEPTIC SHOCK TRIALS: A SYSTEMATIC REVIEW
DOI:
https://doi.org/10.53555/h2w52p26Abstract
Background: Septic is a significant global health concern for children, with about 1.2 million cases each year and varying mortality rates up to 50%. Clinical research in pediatric septic shock faces challenges in choosing appropriate outcome measures beyond mortality due to diverse mortality rates and patient populations. As a result, there's a need for comprehensive research to determine the optimal primary outcome measure for intervention trials in pediatric septic shock cases.
Purpose: This study was aimed for an extensive investigation aimed at identifying the primary outcome measure for pediatric septic shock cases.
Result: We compiled 17 articles from PubMed, Springer Nature, SAGE Pub, and Google Scholar. Ultimately, we included 5 articles that met the criteria.
Conclusion: Collectively, these studies emphasize the multifaceted nature of childhood stunting, necessitating comprehensive strategies that encompass education, nutrition, and healthcare to combat its prevalence. The presented studies on pediatric sepsis management provide insights into tailored approaches, emphasizing lactate clearance, Shock Index (SI), Restricted Lactate Solution (RLS), and Hydrocortisone, Ascorbic Acid, and Thiamine (HAT) therapy as potential measures for improving patient outcomes. Despite limitations, these insights contribute to informed clinical decisions and advancements in pediatric sepsis management.
References
Schlapbach LJ, Straney L, Bellomo R, et al. Prognostic accuracy of age-adapted SOFA, SIRS, PELOD-2, and qSOFA for in-hospital mortality among children with suspected infection admitted to the intensive care unit. Intensive Care Med 2018; 44:179–188
Weiss, S. L., Peters, M. J., Alhazzani, W., Agus, M. S. D., Flori, H. R., Inwald, D. P., … Argent, A. C. (2020). Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated
Organ Dysfunction in Children. Pediatric Critical Care Medicine, 21(2), e52–e106. doi:10.1097/pcc.0000000000002
Zimmerman JJ, Banks R, Berg RA, Zuppa A, Newth CJ, Wessel D, et al. Critical Illness Factors Associated With
Long-Term Mortality and Health Related Quality of Life Morbidity Following Community-Acquired Pediatric
Septic Shock. Crit Care Med [Internet] 2020 Mar 1 [cited 2023 Aug 17];48(3):319. Available from: /pmc/articles/PMC7089387/
Souza DC de, Machado FR. Advances in Pediatric Septic Shock: Epidemiology of Pediatric Septic Shock. J Pediatr Intensive Care [Internet] 2019 Mar [cited 2023 Aug 17];8(1):3. Available from: /pmc/articles/PMC6506671/
Wati, D. K., Putu Ayunda Trisnia, Suryawan, I. W. B. ., Windiani, I. G. A. T. ., Suwarba, I. G. N. ., & Gustawan, I. W. . (2023). Correlation of delta shock index and lactate clearance in shock patients treated in pediatric intensive care unit at Prof Dr. I.G.N.G Ngoerah Hospital. Intisari Sains Medis, 14(2), 450–455. https://doi.org/10.15562/ism.v14i2.1641 More Citation Formats
Gupta, S., & Alam, A. (2018). Shock Index-A Useful Noninvasive Marker Associated With Age-Specific Early Mortality in Children With Severe Sepsis and Septic Shock: Age-Specific Shock Index Cut-Offs. Journal of Intensive Care Medicine, 088506661880277. doi:10.1177/0885066618802779
Wald EL, Sanchez-Pinto LN, Smith CM, et al. Hydrocortisone-Ascorbic Acid-Thiamine Use Associated with Lower Mortality in Pediatric Septic Shock. Am J Respir Crit Care Med. 2020;201(7):863-867. doi:10.1164/rccm.2019081543LE
En-Pei Lee, Han-Ping Wu, Oi-Wa Chan, Jainn-Jim Lin, Shao-Hsuan Hsia, Hemodynamic monitoring and management of pediatric septic shock, Biomedical Journal, Volume 45, Issue 1, 2022, Pages 63-73, ISSN 23194170, https://doi.org/10.1016/j.bj.2021.10.004
Balanced Salt Solution Versus Normal Saline in Resuscitation of Pediatric Sepsis: A Randomized, Controlled Trial Sirawut Trepatchayakorn1 & Manee Sakunpunphuk2 & Rujipat Samransamruajkit1 Received: 7 March 2021 /Accepted: 10 May 2021 /Published online: 10 June 2021
Nazir M, Wani W, Dar SA, Mir IH, Charoo BA, Ahmad QI, Wajid S. Lactate clearance prognosticates outcome in pediatric septic shock during first 24h of intensive care unit admission. Journal of The Intensive Care Society. 2019;0(0):1-9. 15.
Yacoub S, Trung TH, Lam PK, Thien VHN, Hai DHT, Phan TQ, Nguyet OPK, Quyen NTH, et al. Cardiohaemodynamic assessment and venous lactate in severe dengue: relationship with recurrent shock and respiratory distress. Plos Negl Trop Dis. 2017;11(7):e0005740.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Licensing
Ninety Nine Publication publishes articles under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This licensing allows for any use of the work, provided the original author(s) and source are credited, thereby facilitating the free exchange and use of research for the advancement of knowledge.
Detailed Licensing Terms
Attribution (BY): Users must give appropriate credit, provide a link to the license, and indicate if changes were made. Users may do so in any reasonable manner, but not in any way that suggests the licensor endorses them or their use.
No Additional Restrictions: Users may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
