ROLE OF THERAPEUTIC HYPOTHERMIA IN IMPROVING OUTCOME AFTER TRAUMATIC BRAIN INJURY: A SYSTEMATIC REVIEW

Authors

  • Joshua Roberto Pratama Faculty of Medicine, Andalas University, Padang, Indonesia Author

DOI:

https://doi.org/10.53555/nnmhs.v9i9.1845

Keywords:

Hypothermia, Intracranial preassure, Traumatic brain injury

Abstract

Introduction: A nondegenerative and noncongenital brain injury caused by external mechanical forces can cause permanent or temporary harm to cognitive, physical, and psychosocial functions and change or diminish awareness. Traumatic brain injury can cause cerebral edema and ICP increase, worsening the lesion. Cellular death can occur minutes to hours after an injury, although negative effects can last 72 hours or more. Therapeutic hypothermia (HT) can lower ICP and protect neurons, improving patient prognosis and lowering mortality.

The aim: This article showed role of therapeutic hypothermia in improving outcome after traumatic brain injury.

Methods: This study demonstrated compliance with all requirements by comparing itself to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 standards. Therefore, the experts were able to ensure that the study was as current as feasible. For this search strategy, publications published between 2013 and 2023 were considered. Several online reference sources, including Pubmed and SagePub, were utilized for this purpose. It was determined not to consider review pieces, previously published works, or works that were only partially completed.

Result: In the PubMed database, the results of our search brought up 112 articles, whereas the results of our search on SagePub brought up 107 articles. The results of the search conducted for the last year of 2013 yielded a total 59 articles for PubMed and 38 articles for SagePub. In the end, we compiled a total of 28 papers, 19 of which came from PubMed and nine of which came from SagePub. We included seven study that met the criteria.

Conclusion: HT has not reduced, but may have increased, mortality in TBI patients in some high-quality studies. However, TBI patients with elevated ICP may benefit from hypothermia as therapy rather than as prophylaxis when initiated within 24 hours.

References

Vedin T, Edelhamre M, Karlsson M, Bergenheim M, Larsson P-A. Management of Traumatic Brain Injury in the Emergency Department: Guideline Adherence and Patient Safety. Qual Manag Health Care. 2017;26(4):190–5.

Ropper AH, Samuel MA. Adams and Victor’s Principles of Neurology. 9 ed. Boston: Mc Graw Hill Companies Inc; 2014.

BIA. Brain Injury [Internet] Brain Injury Assoc. 2018. Tersedia pada: https://www.biausa.org/brain-injury/aboutbrain-injury

Louis E, Mayer S, Rowland L. Merritt’s neurology. New York: Lippincott Williams & Wilkins; 2016.

Shetty VS, Reis MN, Aulino JM, Berger KL, Broder J, Choudhri AF, et al. ACR Appropriateness Criteria Head Trauma. J Am Coll Radiol. Juni 2016;13(6):668–79.

Johnson U, Nilsson P, Ronne E. Favorable outcome in traumatic brain injury patients with impaired cerebral pressure autoregulation when treated at low cerebral perfusion pressure levels. Neurosurg. 2011;168(3):714–21.

Kostic A, Stefanovic I, Novak V. Prognostic significance of intracranial pressure monitoring and intracranial hypertension in severe brain trauma patients. Med Pregl. 2011;64(9):461–5.

Easter JS, Haukoos JS, Meehan WP, Novack V, Edlow JA. Will Neuroimaging Reveal a Severe Intracranial Injury in This Adult With Minor Head Trauma?: The Rational Clinical Examination Systematic Review. JAMA. Desember 2015;314(24):2672–81.

Sorrentino E, Diedler J, Kasprowicz M. Critical thresholds for cerebrovascular reactivity after traumatic brain injury.

Neurocrit Care. 2012;16(2):258–66.

Dixon J, Comstock G, Whitfield J, Richards D, Burkholder TW, Leifer N, et al. Emergency department management of traumatic brain injuries: A resource tiered review. African J Emerg Med Rev africaine la Med d’urgence. September 2020;10(3):159–66.

Salasky VR, Chang W-TW. Neurotrauma Update. Emerg Med Clin North Am. Februari 2023;41(1):19–33.

Drewry A, Mohr NM. Temperature Management in the ICU. Crit Care Med. Juli 2022;50(7):1138–47.

Du Q, Liu Y, Chen X, Li K. Effect of Hypothermia Therapy on Children with Traumatic Brain Injury: A MetaAnalysis of Randomized Controlled Trials. Brain Sci. Juli 2022;12(8).

Fujita M, Oda Y, Kaneda K, Kaneko T, Suehiro E, Dohi K, et al. Temperature difference between jugular bulb and pulmonary artery is associated with neurological outcome in patients with severe traumatic brain injury: A post hoc analysis of a brain hypothermia study. PLoS One. 2023;18(5):e0285525.

Andrews PJ, Sinclair HL, Rodríguez A, Harris B, Rhodes J, Watson H, et al. Therapeutic hypothermia to reduce intracranial pressure after traumatic brain injury: the Eurotherm3235 RCT. Health Technol Assess. Agustus 2018;22(45):1–134.

Cooper DJ, Nichol AD, Bailey M, Bernard S, Cameron PA, Pili-Floury S, et al. Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial. JAMA. Desember 2018;320(21):2211–20.

Rosario BL, Horvat CM, Wisniewski SR, Bell MJ, Panigrahy A, Zuccoli G, et al. Presenting Characteristics Associated With Outcome in Children With Severe Traumatic Brain Injury: A Secondary Analysis From a Randomized, Controlled Trial of Therapeutic Hypothermia. Pediatr Crit care Med a J Soc Crit Care Med World Fed Pediatr Intensive Crit Care Soc. Oktober 2018;19(10):957–64.

Tang C, Bao Y, Qi M, Zhou L, Liu F, Mao J, et al. Mild induced hypothermia for patients with severe traumatic brain injury after decompressive craniectomy. J Crit Care. Juni 2017;39:267–70.

Andrews PJD, Sinclair HL, Rodriguez A, Harris BA, Battison CG, Rhodes JKJ, et al. Hypothermia for Intracranial Hypertension after Traumatic Brain Injury. N Engl J Med. Desember 2015;373(25):2403–12.

Flynn LMC, Rhodes J, Andrews PJD. Therapeutic Hypothermia Reduces Intracranial Pressure and Partial Brain Oxygen Tension in Patients with Severe Traumatic Brain Injury: Preliminary Data from the Eurotherm3235 Trial. Ther Hypothermia Temp Manag. September 2015;5(3):143–51.

Quintard H, Ichai C, Payen J. The Stress Response after Traumatic Brain Injury: Metabolic and Hormonal Aspects. Springer Int Publ Switz. 2016;12(3):78–83.

Rosahl SC, Covarrubias C, Wu JH, Urquieta E. Staying Cool in Space: A Review of Therapeutic Hypothermia and Potential Application for Space Medicine. Ther Hypothermia Temp Manag. Juni 2022;12(2):115–28.

Escamilla-Ocañas CE, Albores-Ibarra N. Current status and outlook for the management of intracranial hypertension after traumatic brain injury: decompressive craniectomy, therapeutic hypothermia, and barbiturates. Neurologia. Juni 2023;38(5):357–63.

Thayyil S, Montaldo P, Krishnan V, Ivain P, Pant S, Lally PJ, et al. Whole-Body Hypothermia, Cerebral Magnetic Resonance Biomarkers, and Outcomes in Neonates With Moderate or Severe Hypoxic-Ischemic Encephalopathy Born at Tertiary Care Centers vs Other Facilities: A Nested Study Within a Randomized Clinical Trial. JAMA Netw open. Mei 2023;6(5):e2312152.

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Published

2023-09-09

How to Cite

Pratama, J. R. (2023). ROLE OF THERAPEUTIC HYPOTHERMIA IN IMPROVING OUTCOME AFTER TRAUMATIC BRAIN INJURY: A SYSTEMATIC REVIEW. Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 9(9), 13-19. https://doi.org/10.53555/nnmhs.v9i9.1845

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