THE EFFICACY OF ANTIBIOTICS IN ACUTE APPENDICITIS TREATMENT: A COMPREHENSIVE SYSTEMATIC REVIEW
DOI:
https://doi.org/10.61841/3qw8z628Keywords:
Appendicitis, acute, antibiotics, management, efficacy.Abstract
Background: Acute appendicitis has been the most common cause of lower abdominal pain leading to emergency visits worldwide. To avoid major complications, appendectomy has remained the standard treatment for uncomplicated acute appendicitis for over a century.
The aim: The aim of this study to show about the efficacy of antibiotics in acute appendicitis treatment.
Methods: By the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. This search approach, publications that came out between 2014 and 2024 were taken into account. Several different online reference sources, like Pubmed, SagePub, and Sciencedirect were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.
Result: Five publications were found to be directly related to our ongoing systematic examination after a rigorous three-level screening approach. Subsequently, a comprehensive analysis of the complete text was conducted, and additional scrutiny was given to these articles.
Conclusion: The therapeutic effects of antibiotics and appendicectomy were comparable for the treatment of acute appendicitis.
References
Fitzmaurice GJ, McWilliams B, Hurreiz H, Epanomeritakis E. Antibiotics versus appendectomy in the management of acute appendicitis: A review of the current evidence. Can J Surg. 2011;54(5):307–14.
Bolakale-Rufai I, Irabor D. Medical treatment: An emerging standard in acute appendicitis? Niger Med J. 2019;60(5):226.
Xu H, Yang S, Xing J, Wang Y, Sun W, Rong L, et al. Comparison of the efficacy and safety of antibiotic treatment and appendectomy for acute uncomplicated appendicitis: a systematic review and meta-analysis. BMC Surg [Internet]. 2023;23(1):1–18. Available from: https://doi.org/10.1186/s12893-023-02108-1
Poprom N, Numthavaj P, Wilasrusmee C, Rattanasiri S, Attia J, McEvoy M, et al. The efficacy of antibiotic treatment versus surgical treatment of uncomplicated acute appendicitis: Systematic review and network metaanalysis of randomized controlled trial. Am J Surg [Internet]. 2019;218(1):192–200. Available from: https://doi.org/10.1016/j.amjsurg.2018.10.009
Weledji EP, Zisuh A V., Ngounou E. Management of appendicitis: appendicectomy, antibiotic therapy, or both? Ann Med Surg. 2023;85(4):897–901.
Akbar HF, Kareem T, Saleem N, Seerat MI, Hussain MI, Javed I, et al. The Efficacy of Conservative Management in Uncomplicated Acute Appendicitis - A Single-Center Retrospective Study. Cureus. 2022;14(Appac Iii):10–5.
Picard C, Abbo O, Munzer C, Ricco L, Dubois D, Lemoine C, et al. Non-operative treatment of acute appendicitis in children: Clinical efficacy of amoxicillin-clavulanic acid in a retrospective single-centre study. BMJ Paediatr Open. 2023;7(1):1–6.
Haijanen J, Sippola S, Grönroos J, Rautio T, Nordström P, Rantanen T, et al. Optimising the antibiotic treatment of uncomplicated acute appendicitis: A protocol for a multicentre randomised clinical trial (APPAC II trial). BMC Surg. 2018;18(1):1–11.
A Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis. N Engl J Med. 2020;383(20):1907–19.
Steiner Z, Buklan G, Gutermacher M, Litmanovitz I, Landa T, Arnon S. Conservative antibiotic treatment for acute uncomplicated appendicitis is feasible. Pediatr Surg Int [Internet]. 2018;34(3):283–8. Available from: http://dx.doi.org/10.1007/s00383-018-4226-4
Liu ZH, Li C, Zhang XW, Kang L, Wang JP. Meta-analysis of the therapeutic effects of antibiotic versus appendicectomy for the treatment of acute appendicitis. Exp Ther Med. 2014;7(5):1181–6.
Chin X, Mallika Arachchige S, Orbell-Smith JL, Da Rocha D, Gandhi A. Conservative Versus Surgical Management of Acute Appendicitis: A Systematic Review. Cureus. 2024;16(1):1–10.
Yadao S, Lamture Y, Huse S. Uses of Antibiotics Alone in Case of Uncomplicated Appendicitis. Cureus. 2022;14(8).
Matsuda S, Tam T, Singh RP, Kaiser PK, Petkovsek D, Zanella MT, et al. Impact of Insulin Treatment in Diabetic Macular Edema Therapy in Type 2 Diabetes. Can J Diabetes [Internet]. 2015;39(1):73–7. Available from: http://dx.doi.org/10.1016/j.jcjd.2014.06.005
Alajaimi J, Almansoor M, Almutawa A, Almusalam MM, Bakry H. Are Antibiotics the New Appendectomy? Cureus. 2023;15(9):1–9.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Licensing
Ninety Nine Publication publishes articles under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This licensing allows for any use of the work, provided the original author(s) and source are credited, thereby facilitating the free exchange and use of research for the advancement of knowledge.
Detailed Licensing Terms
Attribution (BY): Users must give appropriate credit, provide a link to the license, and indicate if changes were made. Users may do so in any reasonable manner, but not in any way that suggests the licensor endorses them or their use.
No Additional Restrictions: Users may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.