PREVALENCE AND MANAGEMENT OF MATERNAL DEATHS DUE TO ECLAMPSIA AND HELLP SYNDROME: A COMPREHENSIVE SYSTEMATIC REVIEW

Authors

  • Mu’arif Ramadhan General Practitioner, Manggelewa Regional General Hospital, Indonesia Author
  • Yohanes Putu Arianta Obstetric and Gynecology Consultant, Dompu Regional General Hospital, Indonesia Author

DOI:

https://doi.org/10.61841/2sb1s408

Keywords:

Eclampsia, HELLP syndrome, prevalence, treatment

Abstract

Background: Eclampsia and HELLP syndrome, are serious complications during pregnancy, and pose significant risks to both mother and fetus. Early management of eclampsia and HELLP syndrome before delivery may improve the outcomes for patients. This study aims to systematically review the literature on the prevalence and management of eclampsia and HELLP syndrome regarding maternal deaths in the last 10 years.

Methods: This systematic review used the PRISMA 2020 guidelines and focused on full-text English literature published between 2014 and 2024. Editorials and review papers from the same journal, as well as submissions without a DOI, were not considered. Literature was gathered from online databases such as PubMed, SagePub, and ScienceDirect.

Result: In the initial stages, our research team retrieved a total of 9400 articles from reputable sources such as PubMed, SagePub, and Science Direct. After a meticulous three-level screening process, only six articles were deemed directly relevant to our ongoing systematic review and were selected for further analysis through thorough full-text reading.

Conclusion: Eclampsia and HELLP syndrome are both conditions that require treatment. Pregnancy termination and magnesium supplementation prevent eclampsia, while glucocorticoids are crucial for treating HELLP syndrome. Treatment should consider baseline features and long-term implications to address maternal and fetal health and wellbeing.

References

Tjandraprawira, K. D., Kusumah, A. Y., Kamilah, A. Y., Putri, D. I., Ananta, M. R., Sari, S. P., Djuwantono, T., & Petrie, A. (2021). Management and perinatal outcomes of hypertensive disorders of pregnancy in a lowresource setting in Indonesia. 38. https://doi.org/10.1177/20503121211060194

Magley M, Hinson MR. Eclampsia. [Updated 2023 Jan 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554392/

Gracia, P. V., Rojas-suarez, J., Ramos, E., Reyes, O., Collantes, J., Quintero, A., Huertas, E., Calle, A., Turcios, E., & Chon, V. Y. (2015). International Journal of Gynecology and Obstetrics Incidence of eclampsia with HELLP syndrome and associated mortality in Latin America. International Journal of Gynecology and Obstetrics. https://doi.org/10.1016/j.ijgo.2014.11.024

Adorno M, Maher-Griffiths C, Grush Abadie HR. HELLP Syndrome. Crit Care Nurs Clin North Am. 2022 Sep;34(3):277–88.

Khalid F, Mahendraker N, Tonismae T. HELLP Syndrome. In: StatPearls [Internet]. Treasure Island (FL):

StatPearls Publishing; 2024 [cited 2024 Feb 20]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK560615/

Wallace K, Harris S, Addison A, Bean C. HELLP Syndrome: Pathophysiology and Current Therapies. Curr Pharm Biotechnol. 2018;19(10):816–26.

Sun, W.-J., Hu, J., Zhang, Q., & Shan, J.-M. (2023). Administration of corticosteroid therapy for HELLP syndrome in pregnant women: evidences from seven randomized controlled trials. Hypertension in Pregnancy, 42(1), 2276726.https://doi.org/10.1080/10641955.2023.2276726

Gracia, P. V., Ramirez, R., Durán, Y., & Quintero, A. (2017). Magnesium sulfate for 6 vs 24 hours post delivery in patients who received magnesium sulfate for less than 8 hours before birth : a randomized clinical trial. 4–9. https://doi.org/10.1186/s12884-017-1424-3

Wen, S. W., White, R. R., Rybak, N., Gaudet, L. M., Robson, S., Hague, W., Simms-Stewart, D., Carroli, G., Smith, G., Fraser, W. D., Wells, G., Davidge, S. T., Kingdom, J., Coyle, D., Fergusson, D., Corsi, D. J., Champagne, J., Sabri, E., Ramsay, T., … Walker, M. C. (2018). Effect of high dose folic acid supplementation in pregnancy on pre-eclampsia (FACT): double blind, phase III, randomised controlled, international, multicentre trial. BMJ (Clinical Research Ed.), 362, k3478. https://doi.org/10.1136/bmj.k3478

Kang, S., Zhou, L., Wang, X., Li, Y., & Wang, Y. (2019). Effectiveness of high-dose glucocorticoids on hemolysis, elevating liver enzymes, and reducing platelets syndrome. The Journal of International Medical Research, 47(2), 738–747. https://doi.org/10.1177/0300060518809783

Pascoal, A. C. F., Katz, L., Pinto, M. H., Santos, C. A., Braga, L. C. O., Maia, S. B., & Amorim, M. M. R. (2019). Serum magnesium levels during magnesium sulfate infusion at 1 gram/hour versus 2 grams/hour as a maintenance dose to prevent eclampsia in women with severe preeclampsia: A randomized clinical trial. Medicine, 98(32), e16779. https://doi.org/10.1097/MD.0000000000016779

Vousden, N., Lawley, E., Seed, P. T., Gidiri, M. F., Goudar, S., Sandall, J., Chappell, L. C., & Shennan, A. H. (2019). Incidence of eclampsia and related complications across 10 low- and middle- resource geographical regions : Secondary analysis of a cluster randomised controlled trial. PLoS Medicine, April 2016, 1–15.

Cui, C., Ma, S., & Qiao, R. (2020). Prenatal Plasma Fibrinogen Level Predicts Postpartum Hemorrhage of

Patients With HELLP Syndrome. Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 26, 1076029619894057. https://doi.org/10.1177/1076029619894057

Duvekot, J. J., Duijnhoven, R. G., van Horen, E., Bax, C. J., Bloemenkamp, K. W., Brussé, I. A., Dijk, P. H., Franssen, M. T., Franx, A., Oudijk, M. A., Porath, M. M., Scheepers, H. C., van Wassenaer-Leemhuis, A. G., van Drongelen, J., Mol, B. W., & Ganzevoort, W. (2021). Temporizing management vs immediate delivery in early-onset severe preeclampsia between 28 and 34 weeks of gestation (TOTEM study): An open-label randomized controlled trial. Acta Obstetricia et Gynecologica Scandinavica, 100(1), 109–118. https://doi.org/10.1111/aogs.13976

Okusanya, B. O., Oladapo, O. T., Long, Q., Lumbiganon, P., Carroli, G., Qureshi, Z., Duley, L., Souza, J. P., & Gülmezoglu, A. M. (2016). Clinical pharmacokinetic properties of magnesium sulphate in women with preeclampsia and eclampsia. BJOG : An International Journal of Obstetrics and Gynaecology, 123(3), 356–366. https://doi.org/10.1111/1471-0528.13753

Duley, L., Gülmezoglu, A. M., Henderson-Smart, D. J., & Chou, D. (2010). Magnesium sulphate and other anticonvulsants for women with pre-eclampsia. The Cochrane Database of Systematic Reviews, 2010(11), CD000025. https://doi.org/10.1002/14651858.CD000025.pub2

Abbassi-Ghanavati, M., Alexander, J. M., McIntire, D. D., Savani, R. C., & Leveno, K. J. (2012). Neonatal effects of magnesium sulfate given to the mother. American Journal of Perinatology, 29(10), 795–799. https://doi.org/10.1055/s-0032-1316440

Vigil-De Garcia, P., Tejada, O., Minaca, A., Tellez, G., Chon, V., Herrarte, E., Villar, A., & Ludmir, J. (2013). Expectant management of severe preeclampsia remote from term : the MEXPRE Latin Study , a randomized , multicenter clinical trial. American Journal of Obstetrics & Gynecology, 425 (November). https://doi.org/10.1016/j.ajog.2013.08.016

Evensen, A. N. N., Health, P., Anderson, W. J. M., Family, F., Residency, M., & Fontaine, P. P. (2017). Postpartum Hemorrhage: Prevention and Treatment.

Haram, K., Mortensen, J. H., Mastrolia, S. A., & Erez, O. (2016). Disseminated intravascular coagulation in the HELLP syndrome: how much do we really know? Kjell. The Journal of Maternal-Fetal & Neonatal Medicine, 7058(May). https://doi.org/10.1080/14767058.2016.1189897

Yang, L., Ren, C., Mao, M., & Cui, S. (2016). Prognostic Factors of the Efficacy of High-dose Corticosteroid Therapy in Hemolysis , Elevated Liver Enzymes , and Low Platelet Count Syndrome During Pregnancy. Medicine, 95(13), 1–7. https://doi.org/10.1097/MD.0000000000003203

Pourrat, O., Dorey, M., Ragot, S., Hauteclocque, A., & Deruelle, P. (2016). High-Dose Methylprednisolone to Prevent Platelet Decline in Preeclampsia. The American College of Obstetricians and Gynecologist, 128(1), 153– 158. https://doi.org/10.1097/AOG.0000000000001470

Morhart, P., Gärtner, J., Weiss, C., Stumpfe, F. M., Dammer, U., Faschingbauer, F., Fahlbusch, F. B., Beckmann, M. W., & Kehl, S. (2022). Influence of Timing of Antenatal Corticosteroid Administration on Morbidity of Preterm Neonates. In Vivo (Athens, Greece), 36(4), 1777–1784. https://doi.org/10.21873/invivo.12891

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Published

2024-03-27

How to Cite

Ramadhan, M., & Arianta, Y. P. (2024). PREVALENCE AND MANAGEMENT OF MATERNAL DEATHS DUE TO ECLAMPSIA AND HELLP SYNDROME: A COMPREHENSIVE SYSTEMATIC REVIEW. Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 10(3), 380-390. https://doi.org/10.61841/2sb1s408

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