ANTIBIOTICS FOR TREATMENT OF ACUTE APPENDICITIS: A SYSTEMATIC REVIEW
DOI:
https://doi.org/10.61841/505y3779Keywords:
Antibiotics, Acute Appendicitis, EfficacyAbstract
Background: Appendicitis is one of the most common causes of acute abdominal discomfort in adults and children, with a lifetime risk of 8.6% in males and 6.7% in females.
Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and MetaAnalysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2014 and 2023 were taken into account. Several different online reference sources, like Pubmed and SagePub, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.
Result: In the PubMed database, the results of our search brought up 259 articles, whereas the results of our search on SagePub brought up 148 articles. The results of the search conducted for the last year of 2014 yielded a total 15 articles for PubMed and 11 articles for SagePub. In the end, we compiled a total of 6 papers, 4 of which came from PubMed and 2 of which came from SagePub. We included six research that met the criteria.
Conclusion: In summary, when selecting antimicrobial medications to treat acute appendicitis, patients who are especially worried about recurrence of appendicitis should use caution. Patients who failed antibiotic treatment first and underwent surgery later could not possibly result in a higher risk of postoperative complications and the acute appendicitis does not develop to complicated appendicitis in this course, which made antibiotic treatment appealing for patients with acuteacute appendicitis who do not want surgery without having to worry about complications or complicating the original illness.
References
Snyder MJ, Guthrie M, Cagle S. Acute Appendicitis: Efficient Diagnosis and Management [Internet]. Vol. 98. 2018. Available from: www.aafp.org/afp
Kartal İ. Childhood neuroendocrine tumors of the digestive system: A single center experience. Medicine (United States). 2022 Feb 11;101(6):E28795.
Gignoux B, Blanchet MC, Lanz T, Vulliez A, Saffarini M, Bothorel H, et al. Should ambulatory appendectomy become the standard treatment for acute appendicitis? World Journal of Emergency Surgery. 2018 Jun 28;13(1).
Salminen P, Paajanen H, Rautio T, Nordstrom P, Aarnio M, Rantanen T, et al. Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA. 2015;313(23):2340–8.
Otero SP, Metzger JW, Choi BH, Ramaraj A, Tashiro J. It’s time to deconstruct treatment-failure: A randomized controlled trial of nonoperative management of uncomplicated pediatric appendicitis with antibiotics alone. J Pediatr Surg. 2022;57(1):56–62.
Svensson JF, Patkova B, Almstrom M, Naji H, Hall NJ, Eaton S, et al. Nonoperative treatment with antibiotics versus surgery for acute nonperforated appendicitis in children: a pilot randomized controlled trial. Ann Surg. 2015;261(1):67–71.
O’Leary DP, Walsh SM, Bolger J, Baban C, Humphreys H. A Randomized Clinical Trial Evaluating the Efficacy and Quality of Life of Antibiotic-only Treatment of Acute Uncomplicated Appendicitis: Results of the COMMA Trial. Ann Surg. 2021;274(2):240–7.
Sajjad MN, Naumeri F, Hina S. Non-operative treatment versus appendectomy for acute uncomplicated appendicitis: A randomized controlled trial. Pak J Med Sci. 2021 Sep 1;37(5):1276–81.
Flum DR, Davidson GH, Monsell SE, Shapiro NI. A Randomized Clinical Trial Evaluating the Efficacy and Quality of Life of Antibiotic-only Treatment of Acute Uncomplicated Appendicitis: Results of the COMMA Trial. N Engl J Med. 2020;383(20):1907–19.
Ferris M, Quan S, Kaplan BS, Molodecky N, Ball CG. The Global Incidence of Appendicitis: A Systematic Review of Population-based Studies. Ann Surg. 2017;266(2):237–41.
Xu H, Yang S, Xing J, Wang Y, Sun W, Rong L, et al. Comparison of the efficacy and safety of antibiotic treatment and appendectomy for acute uncomplicated appendicitis: a systematic review and meta-analysis. BMC Surg. 2023 Dec 1;23(1).
Downloads
Published
Issue
Section
License

This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.