PLATELET RICH FIBRIN IN DENTISTRY- A REVIEW

Authors

  • Satwik Sham Gundawar Author
  • Sudhindra Baliga Author
  • Nilima Thosar Author
  • Nilesh Rathi Author

DOI:

https://doi.org/10.53555/nnmhs.v4i3.611

Keywords:

Platelet rich fibrin, Growth factors

Abstract

Platelet rich fibrin (PRF) is a fibrin matrix in which platelet cytokines, growth factors and cells are trapped and may be released after a certain time and that can serve as a resorbable membrane. In the present review article, the evolution, preparation of PRF has been described. Autologous PRF is considered to be a healing biomaterial, which has its numerous applications in various disciplines of dentistry. 

References

Bender SA et al Evaluation of demineralized bone matrix paste and putty in periodontal intraosseous defects. Periodontol 2005; 76:768‑77.

Giannobile WV. The potential role of growth and differentiation factors in periodontal regeneration. J Periodontol 1996; 67:545e53.

Garret S. Periodontal regeneration around natural teeth. In: Newman MG, ed. Annals of Periodontology. Chicago: The American Academy of Periodontology, 1996:621e66

Schallhorn RG et al Iliac transplants in periodontal therapy. J Periodontol 1970;41:566580.

Schallhorn RG. Present status of osseous grafting procedures. J Periodontol 1977;48:570576.

Bowers GM et al; Histologic evaluation of new attachment apparatus formation in humans. Part III. J Periodontol 1989;60:683-693.

Bowers GM et al; Histologic evaluation of new attachment apparatus formation in humans. Part II. J Periodontol 1989;60:675-682.

Bowers GM et al; Histologic evaluation of new attachment apparatus formation in humans. Part I. J Periodontol 1989;60:664-674.

Tsao YP et al; Effects of a mineralized human cancellous bone allograft in regeneration of mandibular Class II furcation defects. J Periodontol 2006;77:416-425.

Mellonig JT. Human histologic evaluation of a bovine derived bone xenograft in the treatment of periodontal osseous defects. Int J Periodontics Restorative Dent 2000;20:1929.

Murphy KG et al; Guided tissue regeneration for the treatment of periodontal intrabony and furcation defects. A systematic review. Ann Periodontol 2003;8:266-302.

Machtei EE et al; Guided tissue regeneration in smokers: Effect of aggressive antiinfective therapy in Class II furcation defects. J Periodontol 2003;74:579-584.

Flanary DB; The use of a synthetic skin substitute as a physical barrier to enhance healing in human periodontal furcation defects: A follow-up report. J Periodontol 1991;62: 684-689.

Lekovic V et al; The use of autogenous periosteal grafts as barriers for the treatment of Class II furcation involvements in lower molars. J Periodontol 1991;62:775-780.

Lamb JW et al; A comparison of porous and non-porous Teflon membranes plus demineralized freeze-dried bone allograft in the treatment of Class II buccal/lingual furcation defects: A clinical reentry study. J Periodontol 2001;72:1580-1587.

Simonpietri-C JJ et al; Guided tissue regeneration associated with bovine- derived anorganic bone in mandibular Class II furcation defects. 6-month results at re-entry. J Periodontol 2000;71:904-911.

Hoffmann T et al; A randomized clinical multicentre trial comparing enamel matrix derivative and membrane treatment of buccal Class II furcation involvement in mandibular molars. Part III: patient factors and treatment outcome. J Clin Periodontol 2006;33:575-583.

Pradeep AR et al; A randomized clinical trial of autologous platelet-rich plasma in the treatment of mandibular degree II furcation defects. J Clin Periodontol 2009;36:581-588.

Nevins M et al; Periodontal regeneration in humans using recombinant human plateletderived growth factor-BB (rhPDGF-BB) and allogenic bone. J Periodontol 2003; 74:1282-1292.

Camelo M et al; Periodontal regeneration in human Class II furcations using purified recombinant human plateletderived growth factor-BB (rhPDGF-BB) with bone allograft. Int J Periodontics Restorative Dent 2003;23:213-225. [21] Meyle J. Periodontics: Current concepts and emerging trends. Int J Dent Hyg 2006;4(Suppl. 1):43-49, discussion 5052.

Giannobile WV. The potential role of growth and differentiation factors in periodontal regeneration. J Periodontol 1996;67:545–553

Wang HL et al; The effect of platelet derived growth factor on the cellular response of the periodontium: an autoradiographic study on dogs. J Periodontol 1994;65:429–436.

Lynch SE et al; A combination of platelet-derived growth factor and insulin-like growth factor enhances periodontal regeneration. J Clin Periodontol 1989;16:545–548.

Lynch SE et al; The effects of short-term application of a combination of platelet derived and insulin-like growth factors on periodontal wound healing. J Periodontol 1991;62: 458–467.

Giannobile WV et al; Comparison of canine and non-human primate animal models for periodontal regenerative therapy. Results following a single administration of PDGF/IGF-I. J Periodontol 1994;65: 1158–1168.

Rutherford RB et al; Platelet-derived and insulin-like growth factors stimulate periodontal attachment in monkeys. J Periodontal Res 1992;27:285–290.

Rutherford RB et al; Platelet-derived growth factor and dexamethasone combined with a collagen matrix induce regeneration of the periodontium in monkeys. J Clin Periodontol 1993;20: 537–544.

Sigurdsson TJ et al; Periodontal repair in dogs: recombinant human bone morphogenetic protein-2 significantly enhances periodontal regeneration. J Periodontol 1995;66:131– 138.

Ripamonti U et al;Bone morphogenetic proteins induce periodontal regeneration in the baboon (Papio ursinus). J Periodontal Res 1994;29:439–445.

Sigurdsson TJ et al; Periodontal repair in dogs: evaluation of rhBMP-2 carriers. Int J Periodontics Restorative Dent 1996;16:524–537.

King GN et al; Recombinant human bone morphogenetic protein-2 promotes wound healing in rat periodontal fenestration defects. J Dent Res 1997;76:1460–1467.

Choukroun J et al; An opportunity in perio-implantology: the PRF. Implantodontie 2001;42:55–62.

Dohan Ehrenfest DM et al; Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leukocyte- and platelet- rich fibrin (L-PRF). Trends Biotechnol 2009;27:158–167.

Dohan DM et al; Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:45–50.

Dohan DM et al;Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leukocyte activation: a new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101: 51–55.

Dohan Ehrenfest DM et al; Three-dimensional architecture and cell composition of a Choukrouns platelet-rich fibrin clot and membrane. J Periodontol 2010;81:546–555.

Dohan Ehrenfest DM et al;Slow release of growth factors and thrombospondin-1 in Choukrouns platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors 2009;27:63–69.

Dohan Ehrenfest DM et al; Three-dimensional architecture and cell composition of a Choukroun’s platelet-rich fibrin clot and membrane. J Periodontol 2010;81:546–555

He L et al; A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108:707–713.

Gassling V et al; Platelet-rich fibrin membranes as scaffolds for periosteal tissue engineering. Clin Oral Implants Res 2010; 21:543-549

Sclafani AP. Applications of platelet rich fibrin matrix in facial plastic surgery. Facial Plast Surg 2009;25(4):270-6.

Choukroun J et al; Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on ; bone allograft :maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006 b ; 101: 299-303.

Mazor Z et al; Sinus floor augmentation with simultaneous implant placement using Choukroun’s platelet rich fibrin as the sole grafting material: a radiologic and histologic study at 6 months. J Periodontol 2009; 80: 2056-64

Pradeep AR, Sharma A. Autologous platelet rich fibrin in the treatment of mandibular

Degree II furcation defects: a randomized clinical trial. J Periodontol. 2011;82:1396-1403

Kanakamedala A et al; Platelet-rich-fibrin: A novel root coverage approach. J Indian Soc Periodontol 2009; 13: 5054

Pradeep AR, Sharma A. Treatment of 3-Wall Intrabony Defects in Chronic Periodontitis Subjects With Autologous Platelet Rich Fibrin - A Randomized Controlled Clinical Trial. J Periodontol 2011;82:1314-9

Simon B I et al; Quantitative Evaluation of Extraction Socket Healing Following the Use of Autologous PlateletRich Fibrin Matrix in Humans. Int J Periodontics Restorative Dent 2011;31:285–295.

Peck M T et al; Alveolar Ridge Preservation Using Leukocyte and Platelet-Rich Fibrin: A Report of a Case. Case Reports in Dentistry Volume 2011, Article ID 345048, 5 pages.

Gupta: Socket Preservation at Molar Site using Platelet Rich Fibrin and Bioceramics for Implant Site Development. J Contemp Dent 2013;3(2):102-107.

Steigmann M, Garg AK. A Comparative Study of Bilateral Sinus Lifts Performed with Platelet-Rich Plasma Alone Versus Alloplastic Graft Material Reconstituted with Blood. Implant Dentistry 2005; 14 (3):261-266.

Sumit Narang et al; Modified osteotome sinus floor elevation using combination platelet rich fibrin, bone graft materials, and immediate implant placement in the posterior maxilla: Journal of Indian Society of Periodontology - Vol 19, Issue 4, 2015

Giannobile WV. The potential role of growth and differentiation factors in periodontal regeneration. J Periodontol 1996;67:545e53.

Greenwell H. Committee on research, science and therapy, American Academy of Periodontology. Position paper: guidelines for periodontal therapy. J Periodontol 2001;72:1624–8.

Sander L, Karring T. Healing of periodontal lesions in monkeys following the guided tissue regeneration procedure. A histological study. J Clin Periodontol 1995;22:332–7.

Deodhar AK, Rana RE. Surgical physiology of wound healing: a review. J Postgrad Med 1997;43:52–6.

Giannobile WV. Periodontal tissue engineering by growth factors. Bone 1996;19(Suppl. 1):23S–37S.

Dohan DM et al; Platelet-rich fibrin (PRF): a second-generation platelet concentrate, part I: techno-logical concept and evolution. Oral Surg Oral Med Oral Path Oral Radiol Endod 2006;101:E37–44.

S. Prakash and A. Thakur, “Platelet concentrates: past, present and future,” Journal of Oral and Maxillofacial Surgery, vol. 10, no. 1, pp. 45–49, 2011.

R. E.Marx et al; “Platelet-rich plasma: growth factor enhancement for bone grafts,” Oral Surgery, OralMedicine, Oral Pathology, Oral Radiology, and Endodontics, vol. 85, no. 6, pp. 638–646, 1998.

E. Anitua et al; “The potential impact of the preparation rich in growth factors (PRGF) in different medical fields,” Biomaterials, vol. 28, no. 31, pp. 4551– 4560, 2007.

R. E.Marx, “Platelet rich plasma: evidence to support its use,” Journal of Oral and Maxillofacial Surgery, vol. 64, pp. 489–496, 2004

M. Toffler et al; “Introducing Choukroun’s platelet rich fibrin (PRF) to the reconstructive surgery milieu,”TheJournal of Implant and Advanced Clinical Dentistry, vol. 1, no. 6, pp. 21–32, 2009.

D. M. Dohan, J. Choukroun, A. “Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I:

technological concepts and evolution,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 101, no. 3, pp. E37–E44, 2006.

D. M. Dohan Ehrenfest et al; “Slow release of growth factors and thrombospondin- 1 in Choukroun’s platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies,” Growth Factors, vol. 27, no. 1, pp. 63–69, 2009.

J. Choukroun, A. Diss, A. Simonpieri. “Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV:

clinical effects on tissue healing,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 101, no. 3, pp. E56– E60, 2006.

Dohan DM, Choukroun J, Diss A. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:E45-50.

Dohan DM, Choukroun J, Diss A. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III:

leucocyte activation: a new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:E51-55.

Sharma A, Pradeep AR. Treatment of 3-wall intrabony defects in patients with chronic periodontitis with autologous platelet rich fibrin: a randomized controlled clinical trial. J Periodontol 2011;82(12):1705–12.

Thorat M, Pradeep AR, Pallavi B. Clinical effect of autologous platelet-rich fibrin in the treatment of intra-bony defects: a controlled clinical trial. J Clin Periodontol 2011;38(10):925–32.

S. Prakash and A. Thakur, “Platelet concentrates: past, present and future,” Journal of Oral and Maxillofacial Surgery, vol. 10, no. 1, pp. 45–49, 2011

V. Gupta et al; “Regenerative potential of platelet rich fibrin in dentistry: literature review,” Asian Journal of Oral Health and Allied Sciences, vol. 1, no. 1, pp. 22–28, 2011.

M. Toffler et al; “Introducing Choukroun’s platelet rich fibrin (PRF) to the reconstructive surgery milieu,”The Journal of Implant and Advanced Clinical Dentistry, vol. 1, no. 6, pp. 21–32, 2009.

M.W.Mosesson et al; “The structure and biological features of fibrinogen and fibrin,” Annals of the New York Academy of Sciences, vol. 936, pp. 11–30, 2001.

T. R. Appel et al; “Comparison of three different preparations of platelet concentrates for growth factor enrichment,” Clinical Oral Implants Research, vol. 13, no. 5, pp. 522–528, 2002

N. K. Kiran et al; “Platelet concentrates: a promising innovation in dentistry,” Journal of Dental Sciences and Research, vol. 2, no. 1, pp. 50–61, 2011.

M. Toffler et al; “Introducing Choukroun’s platelet rich fibrin (PRF) to the reconstructive surgery milieu,”TheJournal of Implant and Advanced Clinical Dentistry, vol. 1, no. 6, pp. 21–32, 2009

D. M. Dohan Ehrenfest, L. Rasmusson, and T. Albrektsson, “Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF),” Trends in Biotechnology, vol. 27, no. 3, pp. 158–167, 2009

Jang E-S et al; Restoration of peri-implant defects in immediate implant installations by Choukroun platelet-rich fibrin and silk fibroin powder combination graft. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109; 831-836.

Shobha P et al; Platelet Concentrates: Past, Present and Future Journal of Maxillofacial Oral Surg. Jan-Mar 2011 10(1):45–49

Khiste S Tari R et al;Platelet-Rich Fibrin as a Biofuel for Tissue Regeneration ISRN Biomaterials Volume 2013, Article ID 627367, 6 pages

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Published

2018-03-31

How to Cite

Gundawar, S. S., Baliga, S., Thosar, N., & Rathi, N. (2018). PLATELET RICH FIBRIN IN DENTISTRY- A REVIEW . Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 4(3), 1-7. https://doi.org/10.53555/nnmhs.v4i3.611

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