FUNCTIONAL CONSTIPATION IN CHILDREN: A SYSTEMATIC REVIEW
DOI:
https://doi.org/10.53555/nnmhs.v9i4.1647Keywords:
Children, Constipation, Gastrointestinal, ProbioticAbstract
It is essential to test and diagnose children as soon as possible for functional constipation (FC), which is considered a substantial burden of illness in children. When treated in a timely manner and with the proper medication, babies who have FC have a better chance of making a full recovery. It is estimated that inflammatory bowel disease is responsible for up to 25% of pediatric gastroenterologist visits and 3% of all pediatric outpatient visits globally. It is difficult to estimate the real prevalence of FC in children as a result of the variability of the studies in terms of target population sample, diagnostic criteria, participant ethnicity and environment, technique of data gathering, and lifestyle and psychological characteristics, amongst other considerations. It is possible that the key causes for the worldwide variation in prevalence among studies that have been published are the absence of consensus on diagnostic criteria and cultural variations. Probiotics have the capacity to improve the balance between species, impact intestinal motility by creating lactic acid and short-chain amino acids,and stimulate gut peristalsis by adjusting stool pH. Additionally, probiotics have the potential to increase the number of short-chain amino acids produced in the body. A wide variety of probiotic strains have been the subject of a significant number of investigations. On the other hand, there are not enough evidence available at this time to support the use of probiotics in children who suffer from chronic constipation.
References
Benninga MA, Faure C, Hyman PE, St James Roberts I, Schechter NL, Nurko S. Childhood Functional Gastrointestinal Disorders: Neonate/Toddler. Gastroenterology. 2016 Feb;
Koppen IJN, Nurko S, Saps M, Di Lorenzo C, Benninga MA. The pediatric Rome IV criteria: what’s new? Expert Rev Gastroenterol Hepatol. 2017 Mar;11(3):193–201.
Tabbers MM, Boluyt N, Berger MY, Benninga MA. Clinical practice: diagnosis and treatment of functional constipation. Eur J Pediatr. 2011;170:955–63.
Koppen IJN, Vriesman MH, Saps M, Rajindrajith S, Shi X, van Etten-Jamaludin FS, et al. Prevalence of Functional Defecation Disorders in Children: A Systematic Review and Meta-Analysis. J Pediatr. 2018 Jul;198:121-130.e6.
Kleinman RE, Goulet O-J, Mieli-Vergani G, Sanderson IR, Sherman PM, Shneider BL. Walker’s pediatric gastrointestinal disease: physiology, diagnosis, management. PMPH USA, Ltd; 2018.
Benninga MA, Voskuijl WP, Taminiau JAJM. Childhood constipation: is there new light in the tunnel? J Pediatr Gastroenterol Nutr. 2004 Nov;39(5):448–64.
Boronat AC, Ferreira-Maia AP, Matijasevich A, Wang Y-P. Epidemiology of functional gastrointestinal disorders in children and adolescents: A systematic review. World J Gastroenterol. 2017 Jun;23(21):3915–27.
Kubota M, Ito K, Tomimoto K, Kanazaki M, Tsukiyama K, Kubota A, et al. Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial. Nutrients. 2020 Jan;12(1).
Jarzebicka D, Sieczkowska-Golub J, Kierkus J, Czubkowski P, Kowalczuk-Kryston M, Pelc M, et al. PEG 3350 Versus Lactulose for Treatment of Functional Constipation in Children: Randomized Study. J Pediatr Gastroenterol Nutr. 2019 Mar;68(3):318–24.
van Summeren JJGT, Holtman GA, Kollen BJ, Lisman-van Leeuwen Y, van Ulsen-Rust AHC, Tabbers MM, et al. Physiotherapy for Children with Functional Constipation: A Pragmatic Randomized Controlled Trial in Primary Care. J Pediatr. 2020 Jan;216:25-31.e2.
Benninga MA, Hussain SZ, Sood MR, Nurko S, Hyman P, Clifford RA, et al. Lubiprostone for Pediatric Functional Constipation: Randomized, Controlled, Double-Blind Study With Long-term Extension. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc. 2022 Mar;20(3):602-610.e5.
Xiao YL, Dai N, He SX, Tian DA, Liu S De, Tian Z Bin, et al. Efficacy and safety of lubiprostone for the treatment of functional constipation in Chinese adult patients: A multicenter, randomized, double-blind, placebo-controlled trial. J Dig Dis [Internet] 2021 Nov 1;22(11):622–9. Available from: https://doi.org/10.1111/1751-2980.13058
Sanctuary MR, Kain JN, Chen SY, Kalanetra K, Lemay DG, Rose DR, et al. Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms. PLoS One. 2019;14(1):e0210064.
Wegner A, Banaszkiewicz A, Kierkus J, Landowski P, Korlatowicz-Bilar A, Wiecek S, et al. The effectiveness of Lactobacillus reuteri DSM 17938 as an adjunct to macrogol in the treatment of functional constipation in children. A randomized, double-blind, placebo-controlled, multicentre trial. Clin Res Hepatol Gastroenterol. 2018 Oct;42(5):494–500.
Koppen IJN, Velasco-Benítez CA, Benninga MA, Di Lorenzo C, Saps M. Is There an Association between Functional Constipation and Excessive Bodyweight in Children? J Pediatr. 2016 Apr;171:178-82.e1.
Lloyd-Price J, Abu-Ali G, Huttenhower C. The healthy human microbiome. Genome Med. 2016;8(1):51.
Gibson GR, Hutkins R, Sanders ME, et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol. 2017;14(8):491–502.
Hills Jr RD, Pontefract BA, Mishcon HR, Black CA, Sutton SC, Theberge CR. Gut microbiome: profound implications for diet and disease. Nutrients. 2019;11(7):1613.
Huang R, Hu J. Positive Effect of Probiotics on Constipation in Children: A Systematic Review and Meta-Analysis of Six Randomized Controlled Trials. Front Cell Infect Microbiol. 2017;7:153.
Wu RY, Pasyk M, Wang B, Forsythe P, Bienenstock J, Mao Y-K, et al. Spatiotemporal maps reveal regional differences in the effects on gut motility for Lactobacillus reuteri and rhamnosus strains. Neurogastroenterol Motil Off J Eur Gastrointest Motil Soc. 2013 Mar;25(3):e205-14.
Gutiérrez-Castrellón P, Indrio F, Bolio-Galvis A, Jiménez-Gutiérrez C, Jimenez-Escobar I, López-Velázquez G. Efficacy of Lactobacillus reuteri DSM 17938 for infantile colic: Systematic review with network meta-analysis. Medicine (Baltimore). 2017 Dec;96(51):e9375.
Tian H, Ge X, Nie Y, Yang L, Ding C, McFarland L V, et al. Fecal microbiota transplantation in patients with slowtransit constipation: A randomized, clinical trial. PLoS One. 2017;12(2):e0171308.
Giorgio V, Margiotta G, Stella G, Di Cicco F, Leoni C, Proli F, et al. Intestinal Permeability in Children with Functional Gastrointestinal Disorders: The Effects of Diet. Nutrients. 2022;14(8):1578.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Licensing
Ninety Nine Publication publishes articles under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This licensing allows for any use of the work, provided the original author(s) and source are credited, thereby facilitating the free exchange and use of research for the advancement of knowledge.
Detailed Licensing Terms
Attribution (BY): Users must give appropriate credit, provide a link to the license, and indicate if changes were made. Users may do so in any reasonable manner, but not in any way that suggests the licensor endorses them or their use.
No Additional Restrictions: Users may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
