SARS-COV-2, A NEW ETIOLOGICAL AGENT OF GUILLAIN-BARRE SYNDROME: A CASE REPORT

Authors

  • Dr Dilip Kumar Singri Consultant Intensivist, Zenith Super Specialist Hospital, Kolkata Author
  • Dr. Ujjwal Mondal Senior Consultant , Dept of Anaesthesiologist, Zenith Super Specialist Hospital, Kolkata Author
  • Dr. Anirban Kumar Ghosh Senior Consultant , Dept of Anaesthesiologist, Zenith Super Specialist Hospital, Kolkata Author
  • Dr. Rajashish Majumder Senior Consultant , Dept of Gynecology and Obstetrics , Zenith Super Specialist Hospital, Kolkata Author

DOI:

https://doi.org/10.61841/z33gz644

Abstract

Guillain-Barre syndrome (GBS) is an acute progressive polyradiculoneuropathy where body’s immune system  mistakenly attacks the peripheral nerves and their spinal roots.Covid 19 is a highly contagious disease declared as a global pandemic in 2020.  We report a case of GBS in asymptomatic non vaccinated ( against novel corona virus) covid 19 patient. A 18 years old male patient with no co morbidities admitted with 2 days history of sudden onset weakness of all four limbs. He was tested covid 19 RTPCR positive with no previous history of any symptoms of covid 19. His anti SARS COV2 antibody was positive. Nerve conduction velocity study showed severe acute motor neuropathy. He was electively intubated and ventilated, successfully treated with intravenous immunoglobulins. We conclude SARS COV2 can induce immune system without any prodomal symptoms, so we should aware about SARS COV 2 as an etiological agent of GBS.

References

Helm J, Kremer S, Merdji H, et al. Neurologic features in severe SARS-CoV-2 infection. New England Journal of Medicine. 2020; NEJMc2008597. https://doi.org/10.1056/NEJMc2008597

Carod-Artal FJ. Neurological complications of coronavirus and COVID-19. Revista de Neurología. 2020; 70(9):311–322. https://doi.org/10.33588/rn.7009.2020179

Willison HJ, Jacobs BC, van Doorn PA. Guillain-Barré syndrome. The Lancet. 2016; 388(10045):717–727.

Alberti P, Beretta S, Piatti M, et al. Guillain-Barré syndrome related to COVID-19 infection. Neurology: Neuroimmunology & Neuroinflammation. 2020; 7:e741. https://doi.org/10.1212/NXI.0000000000000741

Virani A, Rabold E, Hanson T, et al. Guillain-Barré syndrome associated with SARS-CoV-2 infection. IDCases. 2020; 20:e00771. https://doi.org/10.1016/j.idcr.2020.e00771

Sedaghat Z, Karimi N. Guillain-Barré syndrome associated with COVID-19 infection: a case report. Journal of Clinical Neuroscience. 2020; 76:233–235. https://doi.org/10.1016/j.jocn.2020.04.062

Camdessanche JP, Morel J, Pozzetto B, Paul S, Tholance Y, Botelho-Nevers E. COVID-19 may induce Guillain-Barré syndrome. Revue Neurologique (Paris). 2020; 176:516–518. https://doi.org/10.1016/j.neurol.2020.04.003

Padroni M, Mastrangelo V, Asioli GM, et al. Guillain-Barré syndrome following COVID-19: new infection, old complication? Journal of Neurology. 2020; 267:1877–1879. https://doi.org/10.1007/s00415-020-09849-6

Giannis D, Ziogas IA, Gianni P. Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past. Journal of Clinical Virology. 2020; 127:104362.

Qu J, Wu C, Li X, et al. Profile of immunoglobulin G and IgM antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clinical Infectious Diseases. 2020; 71(16):2255–2258.

Toscano G, Palmerini F, Ravaglia S, et al. Guillain-Barré syndrome associated with SARS-CoV-2. New England Journal of Medicine. 2020; 382:2574–2576. https://doi.org/10.1056/NEJMc2009191

Scheidl E, Canseco DD, Hadji-Naumov A, Bereznai B. Guillain-Barré syndrome during SARS-CoV-2 pandemic: a case report and review of recent literature. Journal of the Peripheral Nervous System. 2020; 25:204–207. https://doi.org/10.1111/jns.12382

Araújo NM, Ferreira LC, Dantas DP, et al. First report of SARS-CoV-2 detection in cerebrospinal fluid in a child with Guillain-Barré syndrome. Pediatric Infectious Disease Journal. 2021; 40(7):e274–e276. https://doi.org/10.1097/INF.0000000000003146

Downloads

Published

2026-02-05

How to Cite

Singri, D. K. ., Mondal, U. ., Ghosh, A. K. ., & Majumder, R. . (2026). SARS-COV-2, A NEW ETIOLOGICAL AGENT OF GUILLAIN-BARRE SYNDROME: A CASE REPORT. Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 12(1), 25-28. https://doi.org/10.61841/z33gz644