CHRONIC IRRITANT CONTACT DERMATITIS MANAGED WITH BARRIER REPAIR: A CASE REPORT ON THE ROLE OF CERAMIDE AND HYALURONIC ACID
DOI:
https://doi.org/10.61841/9yr0rx69Keywords:
Chronic irritant contact dermatitis, Ceramides, Hand eczema, Hyaluronic acid, Skin barrier, Stratum corneum, Topical therapy.Abstract
Introduction: Chronic irritant contact dermatitis (ICD) is a prevalent inflammatory skin condition driven by cumulative exposure to weak irritants, leading to profound epidermal barrier dysfunction. Management strategies are increasingly focused on restoring barrier integrity as a primary therapeutic goal. This report discusses the synergistic roles of exogenous ceramides in structurally replenishing the depleted intercellular lipid matrix and of hyaluronic acid in providing potent hydration, facilitating cellular repair, and modulating the inflammatory microenvironment.
Case Illustration: We present the case of a 38-year-old female healthcare worker with a multi-year history of chronic hand eczema. Clinical examination revealed erythema, scaling, lichenification, and painful fissures on the dorsal and interdigital aspects of her hands, consistent with chronic ICD. After failing to respond adequately to intermittent topical corticosteroids, she was managed with a strict irritant avoidance protocol and a twice-daily application of a topical emollient containing a physiological lipid mixture of ceramides and hyaluronic acid. Significant improvement in all clinical parameters, including resolution of fissures and reduction in erythema and pruritus, was observed within four weeks of follow-up.
Conclusion: This case highlights the efficacy of a targeted barrier repair strategy using ceramides and hyaluronic acid as a primary, pathophysiology-directed therapy for chronic ICD, offering a valuable alternative or adjunct to conventional anti-inflammatory treatments.
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