THE EFFECT OF BARIATRIC SURGERY ON BREAST CANCER INCIDENCE AND CHARACTERISTICS: A COMPREHENSIVE SYSTEMATIC REVIEW
DOI:
https://doi.org/10.61841/vgrh9754Keywords:
Breast cancer, cancer incidence, bariatric surgeryAbstract
Background: Obesity elevates estrogen levels and pro-inflammatory cytokines, increasing breast cancer risk via macrophage migration to breast tissue and stimulating epithelial proliferation. Observational studies suggest that intentional weight loss, such as through bariatric surgery, can mitigate this risk. This study aims to conduct a comprehensive systematic review, focusing on the impact of bariatric surgery on breast cancer incidence and characteristics using recent literature.
Methods: The systematic review followed PRISMA 2020 standards and examined full-text English literature published between 2014 and 2024. This review excluded editorials, review papers from the same journal, and submissions without a DOI. Literature was sourced from online platforms such as PubMed, SagePub, and SpringerLink.
Result: A total of 1,011 articles s were retrieved from online databases (PubMed, SagePub, and SpringerLink). After three rounds of screening, five articles directly relevant to the systematic review were selected for full-text reading and analysis.
Conclusion: Bariatric surgery decreases overall cancer risk in women, especially for breast cancer, by lowering estrogen levels and altering tumor biology. It also improves glucose homeostasis and reduces insulin resistance, both linked to higher cancer risk.
References
Doumouras AG, Lovrics O, Paterson JM, Sutradhar R, Paszat L, Sivapathasundaram B, et al. Bariatric Surgery and Breast Cancer Incidence: a Population-Based, Matched Cohort Study. OBES SURG. 2022 Apr 1;32(4):1261–9. Available from: https://doi.org/10.1007/s11695-022-05946-9
Winder AA, Kularatna M, MacCormick AD. Does Bariatric Surgery Affect the Incidence of Breast Cancer Development? A Systematic Review. OBES SURG. 2017 Nov 1;27(11):3014–20. Available from: https://doi.org/10.1007/s11695-017-2901-5
Zhang K, Luo Y, Dai H, Deng Z. Effects of Bariatric Surgery on Cancer Risk: Evidence from Meta-analysis. OBES SURG. 2020 Apr;30(4):1265–72. Available from: http://link.springer.com/10.1007/s11695-019-04368-4
Lovrics O, Butt J, Lee Y, Lovrics P, Boudreau V, Anvari M, et al. The effect of bariatric surgery on breast cancer incidence and characteristics: A meta-analysis and systematic review. The American Journal of Surgery. 2021 Oct 1;222(4):715–22. Available from: https://www.sciencedirect.com/science/article/pii/S0002961021001513
Anveden Å, Taube M, Peltonen M, Jacobson P, Andersson-Assarsson JC, Sjöholm K, et al. Long-term incidence of female-specific cancer
after bariatric surgery or usual care in the Swedish Obese Subjects Study. Gynecologic
Oncology.2017May1;145(2):224–9.Availablefrom: https://www.sciencedirect.com/science/article/pii/S0090825817301580
Schauer DP, Feigelson HS, Koebnick C, Caan B, Weinmann S, Leonard AC, et al. Bariatric Surgery and the Risk of Cancer in a Large Multisite Cohort. Annals of Surgery. 2019 Jan;269(1):95. Available from: https://journals.lww.com/annalsofsurgery
/abstract/2019/01000/bariatric_surgery_and_the_risk_of_cancer_in_a. 21.aspx
Hassinger TE, Mehaffey JH, Hawkins RB, Schirmer BD, Hallowell PT, Schroen AT, et al. Overall and Estrogen Receptor–Positive Breast Cancer Incidences Are Decreased Following Bariatric Surgery. OBES SURG. 2019 Mar 1;29(3):776–81. Available from: https://doi.org/10.1007/s11695-018-3598-9
Feigelson HS, Caan B, Weinmann S, Leonard AC, Powers JD, Yenumula PR, et al. Bariatric Surgery is Associated With Reduced Risk of Breast Cancer in Both Premenopausal and Postmenopausal Women. Annals of Surgery. 2020 Dec;272(6):1053. Available from: https://journals.lww.com/annalsofsurgery/abstract/2020/12000/bariatric_surgery_is_associated_with_reduced_r isk.29.aspx
Heshmati K, Harris DA, Rosner B, Pranckevicius E, Ardestani A, Cho N, et al. Association of Bariatric Surgery Status with Reduced HER2+ Breast Cancers: a Retrospective Cohort Study. OBES SURG. 2019 Apr 1;29(4):1092–8. Available from: https://doi.org/10.1007/s11695-018-03701-7
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Rokhim Suryadi, Bambang Supriyo, Yosie Yulanda Putra, Ahsan Auliya, M. Yudhi Hardiyansah (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Licensing
Ninety Nine Publication publishes articles under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This licensing allows for any use of the work, provided the original author(s) and source are credited, thereby facilitating the free exchange and use of research for the advancement of knowledge.
Detailed Licensing Terms
Attribution (BY): Users must give appropriate credit, provide a link to the license, and indicate if changes were made. Users may do so in any reasonable manner, but not in any way that suggests the licensor endorses them or their use.
No Additional Restrictions: Users may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
